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Cat. No.: HheCas13a-100 (for 100pmol)

Cat. No.: HheCas13a-1k (for 1000pmol)

Description

HheCas13a is a crRNA‑guided RNA endonuclease derived from Herbinix hemicellulosilytica. Compared with commonly used Cas13a orthologs such as LwaCas13a and LbuCas13a, HheCas13a exhibits enhanced thermostability. In its RNP form, HheCas13a maintains strong catalytic activity across 37–60 °C, with an optimal reaction temperature of 52 °C. Guided by crRNA, HheCas13a specifically recognizes single‑stranded RNA (ssRNA) targets and does not strictly depend on a protospacer flanking site (PFS).

HheCas13a also displays robust trans‑cleavage activity (also referred to as collateral or auxiliary cleavage). Once HheCas13a binds crRNA and the target RNA to form a ternary complex, the enzyme becomes activated and nonspecifically cleaves surrounding ssRNA molecules in the reaction mixture. This property has been widely applied in the development of rapid nucleic acid detection assays.

Storage