Cas14a1, an endonuclease, can specifically bind and cleave the target ssDNA under the guidance of tracrRNA:crRNA (or sgRNA).
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Cat. No.: Cas14a1-100 (for 100pmol)
Cat. No.: Cas14a1-1k (for 1000pmol)
Compared with other Cas proteins, the molecular weight of Cas14 protein is generally smaller (400-700aa). Similar to Cas12, Cas14a1 can also bind the target nucleic acid and activate its ssDNA trans cleavage activity, so it is can be applied to the molecular detection of target nucleic acid. However, unlike Cas12, there is no PAM binding requirement for Cas14a1. Also, Cas14a1 cleaves only single-stranded DNA (ssDNA) and not double-stranded DNA or single-stranded RNA.