Description

Our photocurable sericin hydrogel (SerMA) is produced by extracting sericin (SS) from alkaline thermal degumming and modifying it with glycidyl methacrylate (GMA) to obtain methacrylated sericin. This material retains the inherent biological activity of sericin while gaining efficient light‑induced crosslinking capability. In aqueous environments, SerMA can rapidly form structurally stable and highly biocompatible three‑dimensional networks under visible‑light irradiation, making it an ideal matrix material for tissue engineering, regenerative medicine, and bio‑3D printing applications.

Product Advantages

• Intrinsic Fluorescence for Convenient Tracing Sericin naturally contains fluorescent groups that emit autofluorescence under common laser excitations such as 405 nm, 488 nm, and 561 nm. This enables direct material imaging and localization without additional staining, greatly facilitating in vitro and in vivo tracking studies.

• Excellent Bioactivity Supporting Cell Adhesion and Proliferation Derived from natural silk, SerMA exhibits strong cell affinity and effectively promotes the adhesion, spreading, and proliferation of various cell types (e.g., HUVEC, C2C12, MC3T3‑E1), providing a biomimetic microenvironment for cell growth.

• Rapid Photocuring with Outstanding Printability Under visible‑light irradiation, SerMA gels within 10 seconds, offering high curing efficiency. Its optimized rheological and photocrosslinking properties make it highly compatible with DLP‑based bioprinting, enabling stable fabrication of complex and fine structures.

• Inherent Biological Functions Sericin possesses natural antioxidant and anticancer activities. In applications such as wound healing and tumor model construction, SerMA provides biological functionalities beyond those of conventional scaffold materials.

• Tunable Performance and Broad Compatibility By adjusting concentration or blending with other hydrogels such as GelMA or HAMA, the mechanical modulus, degradation rate, and optical transparency of SerMA can be easily tuned to meet diverse experimental requirements.

MA Series

• Methacrylated Carboxymethyl Cellulose (CMCMA)
• Methacrylated Chondroitin Sulfate (CSMA)
• Methacrylated Chitosan (ChMA)
• Methacrylated Carboxymethyl Chitosan (CMChMA)
• Tri‑Arm Poly(ε‑caprolactone) Methacrylate (3ArmPCLMA)
• Methacrylated Gellan Gum (GGMA)
• Methacrylated Hyaluronic Acid (HAMA)
• Methacrylated Sericin (SerMA)
• Methacrylated Sodium Alginate (AlgMA)
• Methacrylated Polyvinyl Alcohol (PVAMA)
• Gelatin Methacryloyl (GelMA)
• Methacrylated Silk Fibroin (SilMA)

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory