• Six Innovative POCT Platforms

    At SBS Genetech, we are at the forefront of building a complete POCT ecosystem — from amplification to detection and room‑temperature stability.

  • Six Innovative POCT Platforms for Molecular Diagnostics

    At SBS Genetech, we are at the forefront of innovative Point‑of‑Care Testing (POCT) technologies, delivering a complete ecosystem that covers every stage of molecular diagnostics — from nucleic acid amplification and ultra‑sensitive detection to rapid result interpretation, reagent stability, and enzyme purity. Our six core platforms work seamlessly together to provide faster, more reliable, and more accessible diagnostic solutions for healthcare, public health, food safety, and environmental monitoring.

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    LAMP (Loop-Mediated Isothermal Amplification) enables high-specificity nucleic acid amplification at 60–65°C using multiple primers. It offers robust sensitivity and flexible readouts via turbidity, fluorescence, or colorimetry. Our proprietary pLAMP system features Hotstart Bst P polymerase (70°C), helicase-assisted primer simplification, and aptamer-based enzyme control for superior performance and pathogen inactivation.

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    RPA (Recombinase Polymerase Amplification) operates at 37–42°C with rapid reaction times and simple primer design. Our RPA Multiplex Fluorescent Lyophilized Kit (Gen-4) supports simultaneous amplification of 2–4 targets, direct DNA/RNA detection, and full compatibility with lateral flow strips — all in a freeze-dried format for room-temperature transport.

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    Our CRISPR platform leverages Cas12 for DNA, Cas13 for RNA, and Cas14 for SNP/small fragment detection. When paired with LAMP or RPA, it forms a dual-layer diagnostic system with unmatched sensitivity and specificity. We offer over 50 Cas nucleases, many in freeze-dried format for ambient shipping, enabling scalable, multiplexed POCT applications across infectious disease, food safety, and precision medicine.

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    Our lateral flow system delivers fast, instrument-free results using test strip technology. Compatible with LAMP, RPA, and CRISPR, it enables visual detection in minutes. Ideal for field diagnostics, outbreak control, and low-resource settings, this platform simplifies molecular testing into a portable, user-friendly format.

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    We provide freeze-dried versions of enzymes and complete reagent kits, ensuring room-temperature stability and transport. This eliminates cold chain dependency, reduces logistics costs, and expands access to diagnostics in remote or emergency settings. LAMP, RPA, and CRISPR reagents are all available in lyophilized formats.

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    Our DNA-Free Enzyme platform delivers ultra-pure reagents with no detectable host DNA (Ct > 40 by qPCR). With over 80 enzymes and mastermixes available, plus custom design and purification services, we ensure high activity, stability, and zero contamination — critical for precision diagnostics and research. Advanced purification prevents non-specific amplification and guarantees reliable results.

  • Integrated POCT Workflow

    1

    Amplification

    Technologies: LAMP & RPA

    Isothermal amplification forms the foundation of rapid molecular diagnostics.

    • LAMP: operates at 60–65°C using multiple primers for high specificity and robust signal generation. Our proprietary pLAMP system features hot-start polymerase (up to 70°C), helicase-assisted primer simplification, and aptamer-controlled enzyme activity for enhanced uniformity and pathogen inactivation.
    • RPA: functions at 37–42°C with fast reaction times and simple primer design. Our RPA Multiplex Fluorescent Lyophilized Kit (Gen-4) enables simultaneous amplification of 2–4 targets, direct DNA/RNA detection, and full compatibility with lateral flow strips — all in a freeze-dried format for ambient transport.
    2

    Ultra-Sensitive Detection

    Technology: CRISPR-Cas Systems

    CRISPR-based detection adds a second layer of specificity and sensitivity.

    • Cas12 targets DNA, Cas13 targets RNA, and Cas14 enables SNP and small-fragment detection.
    • When paired with LAMP or RPA, CRISPR forms a dual-layer diagnostic system with ultra-low detection limits.
    • SBS Genetech offers over 50 Cas proteins, many in freeze-dried format for room-temperature shipping and field deployment.
    3

    Visual Readout

    Technology: Lateral Flow System

    Lateral flow strips provide rapid, instrument-free result interpretation.

    • Compatible with LAMP, RPA, and CRISPR amplification systems
    • Delivers clear visual results in minutes
    • Ideal for infectious disease screening, food safety, and point-of-care diagnostics in low-resource settings
    4

    Preservation & Transport

    Technology: Freeze‑Drying System Lyophilization ensures reagents remain stable without cold chain logistics.

    • Freeze‑dried versions of LAMP, RPA, and CRISPR reagents available
    • Room‑temperature storage and shipping reduce costs and expand access
    • Critical for emergency diagnostics, field sampling, and resource‑limited regions
    5

    Purity & Accuracy

    Technology: DNA‑Free Enzyme Platform Precision diagnostics demand contamination‑free reagents.

    • SBS Genetech provides over 80 DNA‑free enzymes and mastermixes, verified by qPCR with Ct > 40 or undetectable signal
    • Advanced purification eliminates host DNA, preventing false positives and ensuring reliable amplification
    • Custom enzyme design and purification available for specialized research needs
    • High activity and stability maintained across diverse experimental conditions

  • This kit exemplifies how SBS Genetech’s Six Innovative POCT Platforms converge into a single, powerful diagnostic solution:

    RPA Isothermal Amplification

    Rapid DNA amplification at 37–42°C provides sufficient target copies within 20–30 minutes, enabling fast downstream detection.

    CRISPR Cas12a Detection

    Cas12a forms a complex with crRNA, specifically recognizing amplified DNA and trans‑cleaving reporter molecules for ultra‑sensitive signal generation.

    Freeze‑Dried Reagents

    All core components are lyophilized, enabling stable transport under ambient conditions or with ice packs. This eliminates the need for dry ice or full cold chain logistics, significantly reducing shipping complexity and cost.

    Lateral Flow Readout

    Results are interpreted visually on nucleic acid test strips within minutes, suitable for field and point‑of‑care testing. This kit is fully compatible with our Lateral Flow Assay for CRISPR SHERLOCK, enabling rapid and reliable readout of Cas12a cleavage activity.

  • FAQs: Six Innovative POCT Platforms

    Your key questions answered about LAMP, RPA, CRISPR, Lateral Flow, Freeze‑Drying, and DNA‑Free Enzymes

  • Cold Spring Harbor Laboratory - SBS Genetech

    SBS Genetech is a long-term sponsor of

    Cold Spring Harbor Laboratory

  • Contact

    For more information, please fill out the provided form or contact us directly by E-mail

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