Description

Poly(ethylene glycol) diacrylate (PEGDA) is a reactive and biocompatible macromer that has become a core component in the development of functional hydrogels. Its unique molecular structure provides tunable mechanical properties, excellent hydrophilicity, and convenient processing characteristics. When combined with ultraviolet (UV) curing technologies, PEGDA enables the rapid fabrication of hydrogels with precise architectures, making it widely applicable in tissue engineering, biofabrication, and 3D bioprinting.

Product Applications

• Tissue‑Engineering Scaffolds PEGDA hydrogels can mimic the mechanical environments of different tissues by adjusting molecular weight and crosslinking density. For example, in peripheral nerve repair, hydrogels constructed from high‑molecular‑weight PEGDA (e.g., ≥6000 Da) form a loose network that allows axonal penetration and extension. When combined with bioactive components such as chitosan, these scaffolds can further promote vascular cell proliferation and accelerate nerve regeneration.
• 3D Biofabrication Materials Leveraging rapid UV‑induced curing, PEGDA hydrogels can be processed via DLP, SLA, and other 3D‑printing technologies to create complex architectures. Examples include printing stem‑cell‑laden PEGDA hydrogels for constructing biomimetic skin or tumor models. The customizable network structure also provides directional “channels” for guided cell growth, such as axonal guidance pathways in multi‑channel nerve conduits.
• Drug‑Delivery and Controlled‑Release Systems High‑molecular‑weight PEGDA hydrogels possess a loose polymer network capable of encapsulating large biomolecules (e.g., proteins, growth factors). Controlled release can be achieved through gradual swelling or degradation of the hydrogel. For instance, embedding VEGF in PEGDA‑based wound dressings enables sustained release through progressive hydrogel swelling, promoting angiogenesis.
• Cell‑Culture Matrices PEGDA hydrogels with low crosslinking density (typically derived from high‑molecular‑weight PEGDA) provide a soft, tissue‑like microenvironment that regulates cell migration, proliferation, and differentiation. In stem‑cell culture, such compliant networks can promote differentiation toward chondrocytes or neural lineages.

AA Series

• Acrylate‑Modified Poloxamer (F127DA)
• Poly(ethylene glycol) Diacrylate (PEGDA)
• Acryloyl‑Modified RGD Peptide (RGDfk‑AA)

Only for research and not intended for treatment of humans or animals

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