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    RNA-Related

    At SBS Genetech, we are at the forefront of offering comprehensive RNA-related products, ensuring robust DNA-RNA conversion

  • What is Ribonucleic Acid (abbreviated as RNA)?

    A Ribonucleotide Molecule

    Consists of phosphate, ribose and base

    Genetic Information Carrier

    Existing in biological cells, some viruses and viroids

    A Chain-Like Molecule

    Condensed by ribonucleotides via phosphodiester bonds

    Four Bases

    A (adenine), G (guanine), C (cytosine) and U (uracil)

  • DNA-RNA Conversion​

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    Transcription of DNA to RNA

    A strand of DNA is used as a template for synthesizing a strand of RNA by RNA polymerase (e.g. T7 Thermostable RNA Polymerase). During this process, RNA polymerase binds to a site called the promoter and starts copying the nucleotides, where deoxyribonucleotides are replaced by ribonucleotides.

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    Reverse Transcription of RNA to DNA

    Complementary DNA (cDNA) is generated from an RNA template by reverse transcriptase (e.g. Ultra Thermo-stable M-MLV Reverse Transcriptase). During this process, RNasin is usually used to prevent the degradation of the RNA templates.

  • Evolution of Reverse Transcriptase

    Faster, Higher, Stronger!

    1

     

    Active at 50°C

    2

     

    Active at 65°C

    • High reverse transcription efficiency
    • High heat resistance
    • High fidelity
    • Tolerant to complex secondary structure RNA
    3

     

    Active at 72°C

    • Higher reverse transcription efficiency
    • Higher heat resistance
    • Higher fidelity
    • More tolerant to complex secondary structure RNA

  • mRNA Synthesis

    Offering high-quality building blocks for mRNA synthesis

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    High-quality Building Blocks

    With the rapid development of biotech, the mRNA vaccine prepared by RNA in vitro synthesis has a great potential for the prevention of many diseases such as tumors, infectious diseases, and chronic diseases. At SBS Genetech, we are at the forefront of offering high-quality building blocks for mRNA synthesis. Our building blocks are free of RNase and DNase and are suitable for any molecular biology application that requires pure ribonucleotides.

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    Backbone: NTPs

    100mM Ribonucleotide Triphosphate (NTP or rNTP) is a ready-to-use solution of NTP (UTP, CTP, GTP, or ATP) at a concentration of 100mM, whose purity is up to 99% (HPLC). It is free of RNase and DNase, and suitable for any molecular biology application that requires pure ribonucleotides.

  • S-adenosylmethionine (SAM)

    S-adenosylmethionine (SAM) is an auxiliary substrate involved in methyl transfer reactions. It is synthesized by adenosine triphosphate and methionine under the action of methionine adenosyltransferase in vivo.

    Pseudo UTP Sodium Solution

    Pseudo UTP has been recognized as the 5th nucleotide because it is the most abundant natural modified RNA base. Pseudo UTP can be used to impart desirable mRNA characteristics such as increased nuclease stability, increased translation, or altered interaction of innate immune receptors with in vitro transcribed RNA.

    N1-Me-Pseudo UTP Sodium Solution

    N1-Me-Pseudo UTP sodium solution is chemically synthesized without DNase and RNase contamination. It is one of the most commonly used modified nucleoside triphosphates. It is mostly used in enzyme reaction substrates or coenzymes, such as in vitro transcription, RNA amplification, siRNA synthesis, etc.

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  • RNA-Related​ Products

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  • Cold Spring Harbor Laboratory - SBS Genetech

    SBS Genetech is a long-term sponsor of

    Cold Spring Harbor Laboratory

  • Contact

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