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Cat. No.: TNFA-10 (for 10μg)

Cat. No.: TNFA-100 (for 100μg)

Cat. No.: TNFA-1k (for 1mg)

 

Synonyms    

IFL; IFN; IFNA; IFNA13; IFN-ALPHA; IFN-alphaD


Purity    

>97% by SDS-PAGE and HPLC analyses.


Biological Activity    

Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.0×108IU/mg.


Physical Appearance    

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.


Formulation    

Lyophilized from a 0.2μm filtered solution in PBS, pH7.4, containing 3% Mannitol, 5% Trehalose, 0.05% Tween-80.


Endotoxin    

Less than 0.1EU/μg of rHuIFN-α1a as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.


Category    

Cytokine


Background    

Interferon alpha-1, also named interferon alpha-D, is belonging to the type I interferon family and is encoded by the IFNA1gene in humans. Interferon alpha-1 is expressed in peripheral blood leukocytes and lymphoblastoid cells. IFNα-1 contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. It plays an important role in inducing non-specific resistance against a broad range of viral infections, and also affects cell proliferation and modulates immune responses. IFNα-1a and IFNα-1b are two forms of interferon alpha-1 except for the substitution of alanine for valine at position 137. Interferon-alpha represents a group of related but distinct proteins that share over 95% amino acid sequence homology.


Amino Acid Sequence    

MCDLPETHSL DNRRTLMLLA QMSRISPSSC LMDRHDFGFP QEEFDGNQFQ KAPAISVLHE LIQQIFNLFT TKDSSAAWDE DLLDKFCTEL YQQLNDLEAC VMQEERVGET PLMNADSILA VKKYFRRITL YLTEKKYSPC AWEVVRAEIM RSLSLSTNLQ ERLRRKE


 

Only for research and not intended for treatment of humans or animals

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