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Cat. No.: HCY211H-50 (for 50μg)

Cat. No.: HCY211H-100 (for 100μg)

Description

Cytokeratin 19 fragment antigen (Cy211) is a member of the cytokeratin family, typically expressed in epithelial tissues where it plays a role in forming the filament cytoskeleton of epithelial cells. Cy211 serves as a valuable tumor marker, particularly for non-small cell lung cancer (NSCLC), in conjunction with carcinoembryonic antigen (CEA) and squamous cell carcinoma–associated antigen (SCC). It is also relevant for detecting other epithelial tumors like bladder cancer. The increased levels observed in tumors may result from cell lysis, which releases cell contents, including Cy211, facilitated by proteases that degrade cytokeratin filaments.

Species

Human

Molecular Alias

Cy211

Accession

P08727

Expression Sequence

Protein sequence(P08727, Ser239-Leu400 with C-10*His)

SAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVLGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 20kDa 

Actual: 22kDa

Purity

95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.