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Cat. No.: HCLG4H-50 (for 50μg)

Cat. No.: HCLG4H-100 (for 100μg)

Description

Collagen type IV is a form of collagen predominantly found in the basal lamina. Mutations in the genes coding for collagen IV can lead to Alport syndrome, characterized by thinning and splitting of the glomerular basement membrane. This condition typically presents with isolated hematuria, sensorineural hearing loss, and ocular disturbances, and is usually inherited in an X-linked manner. Additionally, liver fibrosis and cirrhosis are associated with collagen IV deposition in the liver. In individuals with alcoholic liver disease and hepatitis C, serum collagen IV concentrations correlate with hepatic tissue levels of collagen IV and decrease following successful therapy.

Species

Human

Accession

P02462

Expression Sequence

Protein sequence(P02462, Lys28-Lys172, with C-10*His)

KGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

28kDa

Purity

＞95% by SDS-PAGE

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.