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Aae MutS Protein

Aae MutS is a thermostable mismatch repair protein derived from the thermophilic bacterium Aquifex aeolicus. It exhibits DNA-dependent ATPase activity within its optimal reaction temperature range of 65–75 °C. During DNA replication, Aae MutS specifically recognizes mismatched base pairs and loop structures formed by insertions. By tightly binding these erroneous structures, Aae MutS effectively blocks DNA polymerase extension and suppresses error-prone amplification.