DNA methylation is one of the earliest discovered epigenetic regulation mechanisms and is also one of the most deeply studied epigenetic regulation mechanisms. In a broad sense, DNA methylation refers to the chemical modification process in which a specific base on the DNA sequence obtains a methyl group by covalent bonding with S-adenosyl methionine (SAM) as a methyl donor under the catalysis of DNA methyltransferase (DNMT).
Methylation is one of the important research contents of epigenetics. It is closely related to many following events:
- Reprogramming: DNA methylation is an epigenetic process. Unlike DNA sequences inherited directly from parents, methylation patterns extracted from gametes are deleted before embryo implantation, and a new methylation map will be established for each individual.
- Aging: methylation events occur in a highly specific manner during development, simulating the expression pattern of differentiated tissues. Whether methylation changes will affect the aging process needs further study.
- Diseases: DNA methylation also plays a role in several human diseases.
- Environment: Environmental factors affect DNA methylation status and may affect long-term gene expression patterns.
- Diagnosis of human diseases: An emerging and exciting clinical application of DNA methylation is in the field of diagnosis.
At SBS Genetech, we can provide DNA methylation, RNA methylation and related research products. The main products are as follows:
SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory