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Custom LNA Oligo Synthesis
The major advantage of LNA lies in the design options for primers and probes as the Tm can be fine-tuned according to the needs of the desired oligonucleotide. Due to the enhanced binding affinity, shorter probes can be realized and as a result binding specificity to the target DNA and RNA is increased. Hence, LNA oligonucleotides are very well suited for use in antisense protocols, hybridization assays, in situ hybridization probes, dual-labeled probes, molecular beacons, and qPCR primers.
More Details
Increased Thermal Stability of qPCR Probes
- Improved affinity and specificity
- Reduced background fluorescence
- Better signal-to-noise ratio
Enhanced Single Nucleotide Discrimination
- Greatly enhanced discrimination between alleles via single nucleotide polymorphism (SNP)
- Better mismatch discrimination compared to native-state DNA probes
Multiplex qPCR Systems
- Normalization of the Tm across several short sequences with varying GC-content gets accessible
- Optimal design of highly-specific, shorter probes
- Particularly beneficial for microarray and multiplex PCR applications
Antisense Technology
- Enhanced binding affinity to complementary nucleic acids
- High nuclease resistance
- Further increase in nuclease resistance by the introduction of a phosphorothioate backbone
* The price of custom LNA oligo is dependent on the length, yield, and number. Please indicate the specifics in the quote request.
Featured Citations
Interested in seeing published research using our LNA?
Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution
EMBO Rep | 5 Nov 2019 | DOI: https://doi.org/10.15252/embr.201847016
The locked nucleic acids (LNA) targeting ZIKV sfRNA were chemically synthesized and HPLC purified by Beijing SBS Genetech Co., Ltd. For preparation of ZIKV sfRNA-LNA complex sample, ZIKV sfRNA was mixed with LNA in a 1:10 molar ratio and incubated overnight at 4°C, further purified with SEC column, and then exchanged into SAXS buffer as above.
Only for research and not intended for treatment of humans or animals
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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory