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tech@sbsbio.com
Beijing SBS Genetech Co.,Ltd.
Beijing SBS Genetech Co.,Ltd.
broken image

from China, for the World

for Superior Biology Services since 2000

  • Home
  • Product 
    • All Products
    • Custom Services
    • Catalog Products
    • Innovative Systems
    • Nucleic Acid Related
    • Natural Compounds
    • Synthetic Biology
    • Enzymes
  • POCT Solution 
    • LAMP
    • RPA
    • CRISPR
    • DNA-Free Enzymes
    • Freeze-Drying System
    • Lateral Flow System
  • About 
    • About SBS
    • Achievements
    • Ecosystem
    • Legal Statement
  • Contact
  • …  
    • Home
    • Product 
      • All Products
      • Custom Services
      • Catalog Products
      • Innovative Systems
      • Nucleic Acid Related
      • Natural Compounds
      • Synthetic Biology
      • Enzymes
    • POCT Solution 
      • LAMP
      • RPA
      • CRISPR
      • DNA-Free Enzymes
      • Freeze-Drying System
      • Lateral Flow System
    • About 
      • About SBS
      • Achievements
      • Ecosystem
      • Legal Statement
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Beijing SBS Genetech Co.,Ltd.
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Custom LNA Oligo Synthesis

Custom LNA Oligo Synthesis

The major advantage of LNA lies in the design options for primers and probes as the Tm can be fine-tuned according to the needs of the desired oligonucleotide. Due to the enhanced binding affinity, shorter probes can be realized and as a result binding specificity to the target DNA and RNA is increased. Hence, LNA oligonucleotides are very well suited for use in antisense protocols, hybridization assays, in situ hybridization probes, dual-labeled probes, molecular beacons, and qPCR primers.
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More Details

Increased Thermal Stability of qPCR Probes

  • Improved affinity and specificity
  • Reduced background fluorescence
  • Better signal-to-noise ratio

 

Enhanced Single Nucleotide Discrimination

  • Greatly enhanced discrimination between alleles via single nucleotide polymorphism (SNP)
  • Better mismatch discrimination compared to native-state DNA probes

 

Multiplex qPCR Systems

  • Normalization of the Tm across several short sequences with varying GC-content gets accessible
  • Optimal design of highly-specific, shorter probes
  • Particularly beneficial for microarray and multiplex PCR applications

 

Antisense Technology

  • Enhanced binding affinity to complementary nucleic acids
  • High nuclease resistance
  • Further increase in nuclease resistance by the introduction of a phosphorothioate backbone

 

* The price of custom LNA oligo is dependent on the length, yield, and number. Please indicate the specifics in the quote request.

 

Featured Citations

Interested in seeing published research using our LNA?

Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution

EMBO Rep    |     5 Nov 2019    |    DOI: https://doi.org/10.15252/embr.201847016

The locked nucleic acids (LNA) targeting ZIKV sfRNA were chemically synthesized and HPLC purified by Beijing SBS Genetech Co., Ltd. For preparation of ZIKV sfRNA-LNA complex sample, ZIKV sfRNA was mixed with LNA in a 1:10 molar ratio and incubated overnight at 4°C, further purified with SEC column, and then exchanged into SAXS buffer as above.

 

 

Only for research and not intended for treatment of humans or animals

 

 

Journals Using SBS Genetech Products                                       Universities Using SBS Genetech Products

 

 

SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory

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