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Cat. No.: PTLR-0.2 (for 10mM×0.2ml)

Cat. No.: PTLR-5 (for 5mg)

Cat. No.: PTLR-25 (for 25mg)

Description

Pectolinarin, derived from Cirsium chanroenicum, exhibits anti-inflammatory properties. It effectively inhibits the secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Moreover, Pectolinarin demonstrates suppression of cell proliferation and inflammatory response, along with induction of apoptosis, achieved through inactivation of the PI3K/Akt pathway.

Basic Information

• Aliases: Pectolinaroside; Neolinarin
• Source: Cirsium japonicum Fisch. ex DC.; Linaria vulgaris Mill. subsp. sinensis (Bebeaux) Hong
• Compound type: Flavonoids > Flavones
• Chemical Formula: C₂₉H₃₄O₁₅
• Molecular Weight: 622.57
• CAS Number: 28978-02-1
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 125 mg/ml (200.78 mM)
• Solution Preparation: Add 10 mg to 1.61 ml DMSO, or add 6.23 mg to 1 ml DMSO to prepare a 10 mM solution.

Signaling Pathway

PI3K/Akt

In Vitro Study

Pectolinarin upregulates Bax expression and downregulates Bcl-2 expression in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Additionally, it induces inactivation of the PI3K/Akt pathway in RA-FLSs.

In Vivo Study

N/A

Clinical Trial

N/A

Storage

Store at -20°C in the dark, stable for at least one year. Store solid powder at 4°C in the dark, stable for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C in the dark, stable for an estimated six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory