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Cat. No.: HHPGH-50 (for 50μg)

Cat. No.: HHPGH-100 (for 100μg)

Description

Haptoglobin (Hp) is a protein encoded by the HP gene in humans. In blood plasma, haptoglobin binds tightly to free hemoglobin released from erythrocytes, effectively inhibiting its oxidative activity. In contrast, hemopexin binds to free heme. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system, primarily the spleen. Haptoglobin is considered an acute-phase protein, and its plasma concentration changes in response to pathological conditions. Therefore, testing for its concentration is a routine part of clinical practice. Haptoglobin is a highly conserved protein primarily synthesized in the liver and lungs. It is under investigation as a potential biomarker for various diseases, including different types of malignant neoplasms.

Species

Human

Accession

P00738

Expression Sequence

Protein sequence(P00738, Val19-Gln160&Ile162-Asn406, with C-10*His)

VDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAENGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 44.8kDa 

Actual: 57-70kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from date of receipt, -20 to -70 °C as supplied. 

6 months, -20 to -70 °C under sterile conditions after reconstitution.

1 week, 2 to 8 °C under sterile conditions after reconstitution.  

Please avoid repeated freeze-thaw cycles.