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Cat. No.: FRRL-0.2 (for 10mM×0.2ml)

Cat. No.: FRRL-5 (for 5mg)

Cat. No.: FRRL-25 (for 25mg)

Cat. No.: FRRL-100 (for 100mg)

Description

Farrerol is a bioactive constituent of Rhododendron, showcasing a wide array of activities including anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective, and hepatoprotective effects.

Basic Information

• Aliases: -
• Source: Rhododendron mariesii Hemsl. et Wils.
• Compound type: Flavonoids > Flavones > Dihydroflavones
• Chemical Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.31
• CAS Number: 24211-30-1
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 55 mg/ml(183.1 mM); Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
• Solution Preparation: 5mg dissolved in 1.66ml DMSO, or 3.00mg per 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

In Vitro Study

Farrerol significantly reduces the production of inflammatory mediators, including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells by suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation. Moreover, Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through the Nrf2/Keap1 pathway in a microglia cell line. It also inhibits angiogenesis through the Akt/mTOR, Erk, and Jak2/Stat3 signaling pathways. Additionally, Farrerol regulates the expression of inducers of epithelial-mesenchymal transition, overcoming the invasiveness of lung squamous cell carcinoma cells. Lastly, Farrerol ameliorates acetaminophen-induced hepatotoxicity via the activation of Nrf2 and autophagy.

In Vivo Study

Farrerol safeguards dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways.

Clinical Trial

N/A

Storage

Store at -20°C in the dark, stable for at least one year. Store solid powder at 4°C in the dark, stable for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C in the dark, stable for an estimated six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory