Description

With the continuous advancement of DNA technology, an increasing number of DNA-based techniques are being applied in early drug discovery. For example, the combination of chemical synthesis and compound library screening has accelerated the discovery and optimization of lead compounds, expediting the process of identifying drug candidates. However, traditional compound libraries have limitations such as small capacity, lengthy screening cycles, complex purification processes, and limited structural diversity. These limitations result in higher protein consumption, screening costs, and off-target effects, thereby impeding the speed of drug development.

Currently, DNA-encoded libraries (DEL) have emerged as an effective method for drug discovery. DEL libraries offer unparalleled advantages compared to traditional compound libraries:

• Enormous library capacity: DEL libraries can synthesize millions or even billions of different small molecules or macrocycles with diverse structures.
• Rapid synthesis: The synthesis of millions or even billions of molecules in DEL libraries can be completed in just 1-3 months.
• Enable multiplexed and parallel screening of biological targets: DEL libraries allow for the simultaneous screening against multiple targets, reducing the workload and shortening the screening time.

These advantages make DNA-encoded libraries a powerful tool in drug discovery, overcoming the limitations of traditional compound libraries and facilitating the development of new therapeutics.

Features

• Professional synthesis: We provide highly accurate DEL primers to ensure high-quality library construction in subsequent steps.
• Multiple purification methods: Based on the library construction requirements of different DEL projects, we can flexibly offer various purification methods such as DSL (Dual Size Exclusion Chromatography)/PAGE Plus (Polyacrylamide Gel Electrophoresis Plus)/PAGE (Polyacrylamide Gel Electrophoresis)/HPLC (High-Performance Liquid Chromatography).
• Stringent QC (Quality Control) protocols: Each primer undergoes precise LC-MS (Liquid Chromatography-Mass Spectrometry) verification analysis to guarantee the purity and accuracy of each primer.
• Ensuring Consistency: Stable DNA synthesis process to minimize inter-batch variations.

Related: Probes for Quantitative, Real-time PCR, Molecular Beacons, Oligonucleotide Conjugates

SBS Genetech is recognized as one of the global major leading industry players in Oligonucleotide Synthesis by third-party market researchers. For more details, please visit Oligonucleotide Synthesis Services Market landscape, Top Competitor Analysis, Revenue, Sales With Forecast Data from 2022 to 2028.