High-Purity NTPs, dNTPs & ddNTPs

dNTPs (deoxynucleoside triphosphates) are the essential building blocks required for DNA synthesis during PCR.

During amplification, DNA polymerases incorporate dATP, dCTP, dGTP, and dTTP into newly synthesized DNA strands. The quality and concentration of dNTPs directly influence PCR efficiency, amplification accuracy, and reproducibility.

SBS Genetech provides high-purity dNTP mixes and individual dNTP solutions designed for PCR, qPCR, cloning, sequencing, and molecular diagnostic applications.

NTPs and dNTPs differ mainly in their sugar structure and biological function.

NTPs contain a ribose sugar and are used as substrates for RNA synthesis, including in vitro transcription and RNA engineering.

dNTPs contain a deoxyribose sugar and are required for DNA synthesis, including PCR, DNA replication, and sequencing workflows.

Choosing the correct nucleotide type is essential for achieving reliable experimental results.

ddNTPs (dideoxynucleoside triphosphates) are nucleotide analogs used for controlled DNA chain termination. Because ddNTPs lack the 3'-hydroxyl group required for DNA extension, their incorporation stops further DNA synthesis.

They are widely used in:

• Sanger sequencing
• Mutation confirmation
• Clone verification
• Genotyping applications

SBS Genetech provides high-purity nucleotide products with HPLC-verified purity levels of ≥99% for demanding molecular biology applications.

Our quality control processes are designed to ensure:

• High chemical purity
• Reliable lot-to-lot consistency
• Low contamination risk
• Compatibility with sensitive enzymatic reactions

These quality standards support applications including PCR, sequencing, RNA synthesis, and biotechnology development.

Yes.

SBS Genetech provides scalable nucleotide supply solutions for research institutions, biotechnology companies, diagnostic developers, distributors, and industrial customers.

With 25+ years of manufacturing experience, we support customers requiring:

• Large-volume orders
• Long-term supply agreements
• Competitive bulk pricing
• Flexible packaging options

Yes.

SBS Genetech supports OEM and customized nucleotide solutions for companies developing specialized applications or commercial products. Customization options may include:

• Custom formulations
• Customized concentrations
• Special packaging formats
• Bulk manufacturing support

Our technical team works with partners to develop nucleotide solutions according to specific workflow requirements.

For standard DNA amplification workflows, researchers typically use dNTP mixes containing dATP, dCTP, dGTP, and dTTP.

Depending on the application, different formulations may be selected:

• Standard dNTP Mix for routine PCR
• Individual dNTPs for assay optimization
• dNTP/dUTP Mixes for UDG-based contamination control workflows
• Modified dNTPs for specialized amplification applications

Most nucleotide solutions should be stored at -20°C for routine laboratory use.

For long-term storage, lower temperatures such as -70°C or below may be recommended depending on the formulation.

Avoiding repeated freeze-thaw cycles helps maintain nucleotide stability and performance.

Yes.

Beyond research-scale applications, SBS Genetech supports industrial biotechnology workflows requiring reliable nucleotide supply and consistent manufacturing quality.

Our nucleotide solutions can support applications including:

• Molecular diagnostics
• Synthetic biology
• Enzymatic DNA synthesis
• Cell-free systems
• Biotechnology product development