Loop-mediated Isothermal Amplification (LAMP)

The history of LAMP is closely tied to the evolution of Bst polymerases, a field in which SBS Genetech has long been deeply engaged. What began as a strand-displacing DNA polymerase has evolved through successive generations of enzyme engineering, delivering faster amplification, RNA detection capability, hot-start control, and improved reaction robustness.

Today, SBS Genetech’s latest generation of Bst polymerases combines these advances with complete dUTP compatibility for contamination prevention, providing a powerful foundation for next-generation LAMP assays.

As part of SBS Genetech’s LAMP enzyme engineering portfolio, Bst dU-P DNA/RNA Polymerase represents the culmination of multiple generations of optimization, combining hot-start control, DNA/RNA amplification capability, 65–70°C robustness, inhibitor tolerance, and 100% dUTP compatibility into a single next-generation platform.

Lyophilized LAMP Assay Systems are fully pre-mixed, freeze-dried molecular detection solutions designed to simplify nucleic acid amplification workflows while significantly improving reagent stability and transportability. By integrating all essential reaction components into a single lyophilized format, the system enables rapid deployment of DNA and RNA detection assays without the need for cold-chain storage or complex reagent preparation.

Built on SBS Genetech engineered LAMP enzyme technologies, including proprietary polymerase systems, the platform supports robust isothermal amplification across a wide range of diagnostic and research applications.

Available product formats include PrimeIAmp™ HotStart Bst dU-P Basic Microbeads (with UDG) for general-purpose LAMP workflows, and PrimeIAmp™ HotStart Bst dU-P Fluorescent Microbeads (with UDG) optimized for fluorescence-based real-time detection.