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Cat. No.: SCTL-0.2 (for 10mM×0.2ml)

Cat. No.: SCTL-25 (for 25mg)

Cat. No.: SCTL-100 (for 100mg)

Description

Scutellarin, an active flavone isolated from Scutellaria baicalensis, exhibits several pharmacological effects. It down-regulates the STAT3/Girdin/Akt signaling pathway in HCC cells and inhibits the RANKL-mediated MAPK and NF-κB signaling pathways in osteoclasts. Additionally, Scutellarin demonstrates activity against HIV-1IIIB, HIV-1(74V), and HIV-1KM018 with EC50 values of 26 μM, 253 μM, and 136 μM, respectively.

Basic Information

• Aliases: -
• Source: Scutellaria barbata D. Don; Erigeron breviscapus (Vant.) Hand. -Mazz.; Scutellaria baicalensis Georgi
• Compound type: Flavonoids > Flavones
• Chemical Formula: C₂₁H₁₈O₁₂
• Molecular Weight: 462.36
• CAS Number: 27740-01-8
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/ml (216.28 mM)
• Solution Preparation: 5mg dissolved in 1.08ml DMSO, or 4.62mg per 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

STAT3/Girdin/Akt; MAPK; NF-κB

In Vitro Study

Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner and inhibits the migration and invasion of HCC cells in vitro. Additionally, it decreases STAT3 and Girders of actin filaments (Girdin) expression, as well as STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration, and invasion of HCC cells. Moreover, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on Akt phosphorylation, migration, and invasion of HCC cells. Scutellarin inhibits HCC cell metastasis in vivo, migration, and invasion in vitro by downregulating the STAT3/Girdin/Akt signaling. It selectively enhances Akt phosphorylation. Scutellarin is a potential therapeutic agent as it suppresses microglial activation, ameliorating neuroinflammation, and enhances astrocytic reaction. It amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors, among others, thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia, supporting a functional "cross-talk" between the two glial types. Scutellarin suppresses RANKL-mediated osteoclastogenesis, osteoclast bone resorption function, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that scutellarin inhibits RANKL-mediated MAPK and NF-κB signaling pathways, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation.

In Vivo Study

Scutellarin (50 mg/kg/day) significantly mitigates lung and intrahepatic metastasis of HCC tumors in vivo. The number of lung and intrahepatic metastatic tumors in the scutellarin-treated group is significantly lower than that in the controls. Rats treated with scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Additionally, scutellarin enhances eNOS expression compared with SAH rats.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory