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Cat. No.: RMRN-0.2 (for 10mM×0.2ml)

Cat. No.: RMRN-25 (for 25mg)

Cat. No.: RMRN-100 (for 100mg)

Description

Rosmarinic acid exhibits antioxidant, anti-inflammatory, and antimicrobial activities, showcasing promising physiological effects linked to cognitive performance, Alzheimer's disease prevention, kidney disease treatment, and cardioprotection.

Basic Information

• Aliases: Labiatenic acid
• Source: Perilla frutescens (L.) Britt.; Rosmarinus officinalis L.
• Compound type: Phenylpropanoids > Coumarins > Linear Furano-Coumarins
• Chemical Formula: C₁₈H₁₆O₈
• Molecular Weight: 360.31
• CAS Number: 20283-92-5
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/mL (277.54 mM)
• Solution Preparation: Add 5mg to 1.39ml of DMSO, or alternatively, add 3.60mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

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In Vitro Study

Rosmarinic acid (RA) exhibits a multifunctional profile in vitro, characterized by antioxidant effects, as well as inhibition of monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyl transferase (COMT). RA demonstrates antioxidant effects against hydroxyl (HO(•)) and nitric oxide (NO) radicals, with IC50 values of 29.4 μM and 140 μM, respectively, along with lipid peroxidation inhibition (IC50 of 19.6 μM). Moreover, RA exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. In H2O2-treated cells, 2.5 μM of RA scavenges 60% of intracellular ROS, compared to 77% with N-acetyl-L-cysteine (NAC).

In Vivo Study

Rosmarinic acid (RA) is a widely distributed phenolic ester compound found in plants, particularly in the Labiatae family of herbs, such as Rosmarinus officinalis, Salvia miltiorrhiza, and Prunella vulgaris. RA exhibits potent anti-inflammatory properties, as evidenced by its ability to suppress colonic inflammation in mice induced by dextran sulphate sodium (DSS), achieved through dual inhibition of NF-κB and STAT3 activation. In the DSS-induced colitis model, treatment with Rosmarinic acid (30, 60 mg/kg, p.o.) significantly reduces the production of cytokines, indicating its therapeutic potential for inflammatory conditions.

Clinical Trial

NCT00465543: Nasal Polyps, Phase 2; NCT01380015: Osteoarthritis of the Knee, Phase 4.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory