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Cat. No.: RMLIF-10 (for 10μg)

Cat. No.: RMLIF-50 (for 50μg)

Cat. No.: RMLIF-200 (for 200μg)

 

Synonyms    

mitochondrial; MtSSB; single-stranded DNA binding protein 1


Purity    

>95% by SDS-PAGE and HPLC analyses.


Biological Activity    

Data Not Available.


Physical Appearance    

Sterile liquid.


Formulation    

0.2μm filtered concentrated solution in 20mM Tris, pH7.4, 200mM NaCl, 50% Glycerol, 1mM EDTA, 0.5mM DTT.


Endotoxin    

Less than 0.1EU/μg of rSSB as determined by LAL method.


Reconstitution    

N/A


Category    

Others


Background    

Single-stranded DNA-binding protein, or SSB, binds to single-stranded regions of DNA to prevent premature annealing, to protect the single-stranded DNA from being digested by nucleases, and to remove secondary structure from the DNA to allow other enzymes to function effectively upon it. In molecular biology, SSB protein domain in bacteria are important in its function of maintaining DNA metabolism, more specifically DNA replication, repair and recombination. SSB proteins have been identified in organisms from viruses to humans. The only organisms known to lack them are thermoproteales, a group of extremophile archaea, where they have been displaced by the protein ThermoDBP. While many phage and viral SSBs function as monomers and eukaryotes encode heterotrimeric RPA (Replication Protein A), the best characterized SSB is that from the bacteria E. coli which, like most bacterial SSBs exists as a tetramer.


Amino Acid Sequence    

MEEKVGNLKP NMESVNVTVR VLEASEARQI QTKNGVRTIS EAIVGDETGR VKLTLWGKHA GSIKEGQVVK IENAWTTAFK GQVQLNAGSK TKIAEASEDG FPESSQIPEN TPTAPQQMRG GGRGFRGGGR RYGRRGGRRQ ENEEGEEE

Only for research and not intended for treatment of humans or animals

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