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Cat. No.: RMLIF-10 (for 10μg)

Cat. No.: RMLIF-50 (for 50μg)

Cat. No.: RMLIF-200 (for 200μg)

 

Synonyms    

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Small-inducible cytokine C1; Xcl1; Ltn; Scyc1


Purity    

>97% by SDS-PAGE and HPLC analyses.


Biological Activity    

Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is less than 100ng/ml, corresponding to a specific activity of >1.0×104IU/mg.


Physical Appearance    

Sterile Filtered White lyophilized (freeze-dried) powder.


Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.


Endotoxin    

Less than 0.1EU/μg of rRtLymphotactin/XCL1 as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.


Category    

Chemokines


Background    

Chemokine (C motif) ligand (XCL1), as known as lymphotactin, is the only known member of the C-chemokine family and signals through the receptor XCR1, formally known as GPR5. The expression of lymphotactin is abundant in some activated T cells such as activated CD8+ T cells and other class I MHC restricted T cells. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. XCL1 induces its chemotactic function by binding to a chemokine receptor called XCR1. Recombinant Rat XCL1 which is a single non-glycosylated polypeptide chains containing 93 amino acids and it shares approximately 57% and 82% amino acid sequence homology with the human and murine XCL1.


Amino Acid Sequence    

VGTEVLQESI CVSLRTQRLP VQKIKTYTIK EGAMRAVIFV TKRGLRICAD PQAKWVKTAI KTVDGRASAS KSKAETIPTQ AQRSASTAVT LTG

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