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Cat. No.: MTS10-10 (for 10μg)

Cat. No.: MTS10-100 (for 100μg)

Cat. No.: MTS10-500 (for 500μg)


Synonyms    

OTP; IFNT1; IFNT3; IFNT4; IFNT7; IFNT8; IFNT9; TP-07; TP-08; TP-010; IFN-tau-3; IFN-tau-7; IFN-tau-8; IFN-tau-9; IFN-tau-1; Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1


Purity    

>97% by SDS-PAGE and HPLC analyses.


Biological Activity    

Fully biologically active when compared to IFN-alpha. The specific activity determined by a viral resistance assay is no less than 1.0×107IU/mg.


Physical Appearance    

Sterile Filtered White lyophilized (freeze-dried) powder.


Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.


Endotoxin    

Less than 0.1EU/μg of rOvIFN-τ as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.


Category    

Cytokine


Background    

IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β. The current investigation concerns the effect of recombinant ovine IFN-tau (rOvIFN-τ) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN-τ was shown to down regulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in down regulating inflammation in the central nervous system (CNS). IFN-τ did not upregulate the expression of MHC class II on CVE. IFN-τ also inhibited the replication of Theiler's virus in CVE.


Amino Acid Sequence    

CYLSRKLMLD ARENLKLLDR MNRLSPHSCL QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN SP

 

Only for research and not intended for treatment of humans or animals

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