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Cat. No.: RMLIF-10 (for 10μg)

Cat. No.: RMLIF-50 (for 50μg)

Cat. No.: RMLIF-200 (for 200μg)

 

别名(Synonyms)    

Recombinant Human Rho A, 重组人Rho A蛋白, RAS同源基因家族成员A; Ras homolog gene family, member A; Transforming protein RhoA; Rho cDNA clone 12; RHOA; ARH12; ARHA; RHO12


产品简介(Background)    

Beyotime’s recombinant human RhoA (rhRhoA) was expressed in E. coli and purified, which contain the mature form RhoA (1-190aa) with 3X Flag tag at the C-terminus.

RhoA is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. RhoA regulates the dynamic organization of the actin cytoskeleton (polymerization, actomyosin contractility or stress fiber formation) and cellular functions dependent on the dynamic actin cytoskeleton, including cell morphology, polarity, cell adhesion, cell migration/motility, cell protrusion, extracellular action, endocytosis, cell cycle regulation, cytoplasmic division, cell development and its processes such as transcriptional control and cell proliferation. RhoA is also involved in the regulation of microtubule dynamics [1-2].


产品用途(Applications)    

Recombinant Human RhoA is useful in studying RhoA interacting proteins, effectors, GAPs (GTPase-activating proteins) and GEFs (Guanine nucleotide-exchange factors). It can also be used as positive control in Western blots.


外观(Physical appearance)    

Liquid


活性(Biological activity)    

The specific activity of RhoA was 10.9 nmol/min/mg in GPTase-Glo assay.


浓度(Concentration)    

1mg/ml


纯度(Purity)    

≥ 95% by SDS-PAGE


储存液(Storage buffer)    

20mM HEPES (pH7.4), 200mM NaCl, 1mM EDTA, 2mM DTT, 5% glycerol
 

Only for research and not intended for treatment of humans or animals

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