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Cat. No.: RMLIF-10 (for 10μg)

Cat. No.: RMLIF-50 (for 50μg)

Cat. No.: RMLIF-200 (for 200μg)

 

Synonyms    

PTP1B; PTP-1B; rhPTP1B


Purity    

＞95% by SDS-PAGE; no detectable DNase and RNase


Unit definition    

One unit is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH7.5 at 37ºC.


Activity    

＞10U/μg


Physical appearance    

Liquid


Formulation    

1mg/ml in 100mM Tris-HCl (pH7.2 at 25ºC), 100mM NaCl, 1mM EDTA, 50% glycerol.


Endotoxin    

N.A.


Category    

Metabolic enzyme


Description    

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
 

Application    

Study the enzyme kinetics and regulatory mechanisms of PTP1B; targeted substrate dephosphorylation; PTP1B inhibitor screening.

Only for research and not intended for treatment of humans or animals

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