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Cat. No.: MTS10-10 (for 10μg)

Cat. No.: MTS10-100 (for 100μg)

Cat. No.: MTS10-500 (for 500μg)


Synonyms    

AMAC-1; DC-CK1; MIP-4; PARC; Alternative macrophage activation-associated CC chemokine 1; AMAC1CC chemokine ligand 18; AMAC-1Small-inducible cytokine A18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); CKb7; DC-CK1CC chemokine PARC; DCCK1Macrophage inflammatory protein 4; Dendritic cell chemokine 1; MIP4; MIP-4C-C motif chemokine 18; PARCPulmonary and activation-regulated chemokine; SCYA18chemokine (C-C), dendritic; small inducible cytokine A18; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary andactivation-regulated


Purity    

>97% by SDS-PAGE and HPLC analyses.


Biological Activity    

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 1.0-10ng/ml.


Physical Appearance    

Sterile Filtered White lyophilized (freeze-dried) powder.


Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH7.4, 100mM NaCl.


Endotoxin    

Less than 1EU/μg of rHuMIP-4/CCL18 as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.


Category    

Chemokines


Background    

Human CCL18 is encoded by the CCL18 gene located on the chromosome 17. As also named MIP-4, it shares 61% sequence identity to human MIP-1α. CCL18 is mainly expressed by lung and some lymphoid tissues like lymph nodes express CCL18 at low level. It is chemotactic for both activated (CD3+) T cells and nonactivated (CD14-) lymphocytes, but not for monocytes or granulocytes. Involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 plays a role in both humoral and cellmediated immunity responses.


Amino Acid Sequence    

AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA

 

Only for research and not intended for treatment of humans or animals

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