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Cat. No.: MTS10-10 (for 10μg)

Cat. No.: MTS10-100 (for 100μg)

Cat. No.: MTS10-500 (for 500μg)


Synonyms    

MCP-4; C-C motif chemokine 13; chemokine (C-C motif) ligand 13; CKb10; MCP4; MCP-4Monocyte chemoattractant protein 4; MGC17134; NCC-1Monocyte chemotactic protein 4; NCC1Small-inducible cytokine A13; new CC chemokine 1; SCYA13CK-beta-10; SCYL1; small inducible cytokine subfamily A (Cys-Cys), member 13


Purity    

>96% by SDS-PAGE and HPLC analyses.


Biological Activity    

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 10-100ng/ml.


Physical Appearance    

Sterile Filtered White lyophilized (freeze-dried) powder.


Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH7.4, 130mM NaCl.


Endotoxin    

Less than 1EU/μg of rHuMCP-4/CCL13 as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.


Category  

 Chemokines


Background    

Human CCL13 is belonging to the CC chemokine family and is encoded by the gene CCL13 in humans. CCL13 (MCP-4) shares 56-61% sequence identity with MCP-1 (CCL2) and MCP-3 (CCL7) and is 60% identical to Eotaxin (CCL11). CCL13 was a potent chemoattractant for monocytes and eosinophils and stimulated histamine release from basophils. CCL13 can induce a calcium flux in HEK-293 cells transfected with the receptor CCR2B and CCR3. That shows the function receptors of CCL3 are CCR2B and CCR3.


Amino Acid Sequence    

QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT
 

Only for research and not intended for treatment of humans or animals

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