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Cat. No.: IL7-10 (for 10μg)

Cat. No.: IL7-100 (for 100μg)

Cat. No.: IL7-1k (for 1mg)

Synonyms    

Lymphopoietin-1; PBGF; IL-7interleukin-7; interleukin 7


Purity    

>97% by SDS-PAGE and HPLC analyses.
 

Biological Activity    

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine 2E8 cells is less than 0.5ng/ml, corresponding to a specific activity of >2.0×106IU/mg.
 

Physical Appearance    

Sterile Filtered White lyophilized (freeze-dried) powder.
 

Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.
 

Endotoxin    

Less than 1EU/μg of rHuIL-7 as determined by LAL method.
 

Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
 

Category    

Cytokine
 

Background    

Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and also stimulates proliferation of B cells, T cells and NK cells. Murine IL-7 has approximately 65% amino acid sequence identity with human IL-7 and both proteins exhibit cross-species activity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection.
 

Amino Acid Sequence    

DCDIEGKDGK QYESVLMVSI DQLLDSMKEI GSNCLNNEFN FFKRHICDAN KEGMFLFRAA RKLRQFLKMN STGDFDLHLL KVSEGTTILL NCTGQVKGRK PAALGEAQPT KSLEENKSLK EQKKLNDLCF LKRLLQEIKT CWNKILMGTK EH

Only for research and not intended for treatment of humans or animals

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