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Cat. No.: IL13-10 (for 10μg)

Cat. No.: IL13-100 (for 100μg)

Cat. No.: IL13-1k (for 1mg)

Synonyms    

IL-13; P600

Purity    

>97% by SDS-PAGE and HPLC analyses.

Biological Activity    

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1ng/ml, corresponding to a specific activity of >1.0×106IU/mg.

Physical Appearance    

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.

Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4 with 5% trehalose.

Endotoxin    

Less than 1EU/μg of rHuIL-13 as determined by LAL method.

Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 20mM HCl to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category    

Cytokine

Background    

Human Interleukin-13 (IL-13) is expressed by the IL13 gene located on the chromosome 5 and secreted by many cell types, especially T helper type 2 (Th2) cells. The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts antiinflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Human, mouse and rat IL-3 share low homology, but have cross species activity.

Amino Acid Sequence    

GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN

Only for research and not intended for treatment of humans or animals

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