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Cat. No.: IL13V-10 (for 10μg)

Cat. No.: IL13V-100 (for 100μg)

Cat. No.: IL13V-500 (for 500μg)

Synonyms    

IL-13; P600

Purity    

>97% by SDS-PAGE and HPLC analyses.

Biological Activity    

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5ng/ml, corresponding to a specific activity of >2.0×106IU/mg.

Physical Appearance    

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.

Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.2, with 5% trehalose.

Endotoxin    

Less than 1EU/μg of rHuIL-13, Variant as determined by LAL method.

Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category    

Cytokine

Background    

Human Interleukin-13 (IL-13) is expressed by the IL13 gene located on the chromosome 5. IL-13 is a 132 amino acid protein containing a proposed 20 amino acid signal peptide, and shares approximately 30% amino acid sequence homology to human IL-4. Additionally, the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages.
IL-13 variant is a natural variant of IL-13 and has a Q instead of R112 of wild type, which associated with increased risk for asthma development and at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients.

Amino Acid Sequence    

GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGQ FN

Only for research and not intended for treatment of humans or animals

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