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Cat. No.: MTS10-10 (for 10μg)

Cat. No.: MTS10-100 (for 100μg)

Cat. No.: MTS10-500 (for 500μg)


Synonyms    

IFNG; IFG; IFI; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma


Purity    

>97% by SDS-PAGE and HPLC analyses.


Biological

Activity    Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HeLa cells infected with encephalomyocarditis (EMC) virus is less than 10.0ng/ml, corresponding to a specific activity of >1.0×105IU/mg.


Physical Appearance    

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.


Formulation    

Lyophilized from a 0.2μm filtered concentrated solution in 2X PBS, pH7.4, with 5% trehalose.


Endotoxin    

Less than 0.1EU/μg of rEqIFN-γ as determined by LAL method.


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.


Category    

Cytokine


Background    

Interferon-gamma (IFN-γ), also known as Type II interferon or immune interferon, is a cytokine produced primarily by Tlymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally, IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation. Equine IFN-γ shares 73%~82% amino acid sequence identity with bovine, canine, feline, and porcine IFN-γ and 42%~64% with cotton rat, human,murine, rat, and rhesus macaque IFN-γ.


Amino Acid Sequence    

QAAFFKEIEN LKEYFNASNP DVGDGGPLFL DILKNWKEDS DKKIIQSQIV SFYFKLFENL KDNQVIQKSM DTIKEDLFVK FFNSSTSKLE DFQKLIQIPV NDLKVQRKAI SELIKVMNDL SPKANLRKRK RSQNPFRGRR ALQ
 

Only for research and not intended for treatment of humans or animals

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