thumbnail image
tech@sbsbio.com
Beijing SBS Genetech Co.,Ltd.
Beijing SBS Genetech Co.,Ltd.
broken image

from China, for the World

for Superior Biology Services since 2000

  • Home
  • Product 
    • All Products
    • Custom Services
    • Catalog Products
    • Innovative Systems
    • Nucleic Acid Related
    • Natural Compounds
    • Synthetic Biology
    • Enzymes
  • POCT Solution 
    • LAMP
    • RPA
    • CRISPR
    • DNA-Free Enzymes
    • Freeze-Drying System
    • Lateral Flow System
  • About 
    • About SBS
    • Achievements
    • Ecosystem
    • Legal Statement
  • Contact
  • …  
    • Home
    • Product 
      • All Products
      • Custom Services
      • Catalog Products
      • Innovative Systems
      • Nucleic Acid Related
      • Natural Compounds
      • Synthetic Biology
      • Enzymes
    • POCT Solution 
      • LAMP
      • RPA
      • CRISPR
      • DNA-Free Enzymes
      • Freeze-Drying System
      • Lateral Flow System
    • About 
      • About SBS
      • Achievements
      • Ecosystem
      • Legal Statement
    • Contact
    • Login
tech@sbsbio.com
Beijing SBS Genetech Co.,Ltd.
Beijing SBS Genetech Co.,Ltd.
broken image

from China, for the World

for Superior Biology Services since 2000

  • Home
  • Product 
    • All Products
    • Custom Services
    • Catalog Products
    • Innovative Systems
    • Nucleic Acid Related
    • Natural Compounds
    • Synthetic Biology
    • Enzymes
  • POCT Solution 
    • LAMP
    • RPA
    • CRISPR
    • DNA-Free Enzymes
    • Freeze-Drying System
    • Lateral Flow System
  • About 
    • About SBS
    • Achievements
    • Ecosystem
    • Legal Statement
  • Contact
  • …  
    • Home
    • Product 
      • All Products
      • Custom Services
      • Catalog Products
      • Innovative Systems
      • Nucleic Acid Related
      • Natural Compounds
      • Synthetic Biology
      • Enzymes
    • POCT Solution 
      • LAMP
      • RPA
      • CRISPR
      • DNA-Free Enzymes
      • Freeze-Drying System
      • Lateral Flow System
    • About 
      • About SBS
      • Achievements
      • Ecosystem
      • Legal Statement
    • Contact
    • Login
Beijing SBS Genetech Co.,Ltd.
Go Back
Luteolin | 491-70-3

Luteolin | 491-70-3

$26.00 - $157.00
Luteolin (also known as Luteoline), a flavonoid compound, is a potent inhibitor of Nrf2. It possesses anti-inflammatory and anti-cancer properties, inducing apoptosis and cell cycle arrest, and inhibiting metastasis and angiogenesis in various cancer cell lines, including human non-small lung cancer cells.
Select
Quantity
Coming soon
Add to cart
More Details

All products have special prices for bulk purchase, please contact for more details if required.

 

Cat. No.: LTOL-0.2 (for 10mM×0.2ml)

Cat. No.: LTOL-25 (for 25mg)

Cat. No.: LTOL-100 (for 100mg)

 

 

Description

Luteolin (also known as Luteoline), a flavonoid compound, is a potent inhibitor of Nrf2. It possesses anti-inflammatory and anti-cancer properties, inducing apoptosis and cell cycle arrest, and inhibiting metastasis and angiogenesis in various cancer cell lines, including human non-small lung cancer cells.

 

Basic Information

  • Aliases: Luteoline; Digitoflavone; Daphneflavonol; Flavopurpol; Luteolol
  • Source: Siphonostegia chinensis Benth.; Lonicera japonica Thunb.
  • Compound type: Flavonoids > Flavones
  • Chemical Formula: C15H10O6
  • Molecular Weight: 286.24
  • CAS Number: 491-70-3
  • Purity: 98%, HPLC
  • Solvent/Solubility: DMSO: ≥ 100 mg/mL (349.36 mM)
  • Solution Preparation: 5mg can be dissolved in 1.75ml of DMSO, or alternatively, 2.86mg can be dissolved in 1ml of DMSO, to prepare a 10mM solution.

 

Signaling Pathway

-

 

In Vitro Study

Luteolin treatment (0-160 µM; 24 hours; NCI-H460 cells) inhibits the viability of NCI-H460 cells in a concentration-dependent manner. Treatment with Luteolin (20-80 µM; 24 hours; NCI-H460 cells) leads to an accumulation of cells in the S phase. Moreover, treatment with Luteolin (320-580 µM; 48 hours; NCI-H460 cells) induces apoptosis. Additionally, Luteolin treatment (20-80 µM; 24 hours; NCI-H460 cells) increases the protein expression levels of apoptotic regulatory proteins, such as the Bax/Bcl-2 ratio, in a concentration-dependent manner. However, only 80 µM Luteolin inhibits the expression of Bad. Furthermore, Luteolin decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner.

 

In Vivo Study

Luteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) exhibits antioxidant properties and can effectively protect against non-alcoholic steatohepatitis by targeting the pro-inflammatory IL-1 and Il-18 pathways in rats fed with a high carbohydrate/high fat diet.

 

Clinical Trial

NCT03288298: Tongue Neoplasms|Carcinoma, Early Phase 1.

 

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

 

Precautions

  • This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
  • This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
  • For your safety and health, please wear laboratory attire and disposable gloves while handling.

 

 

 

Only for research and not intended for treatment of humans or animals

 

 

Journals Using SBS Genetech Products                                       Universities Using SBS Genetech Products

 

 

SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory

  • background image
    background image
    background image
    background image
    background image
    background image
    background image
  • Featured Publications

    We are honored to create value for our customers and facilitate the development of science

SBS Genetech © Copyright 2000-2025

from China, for the World

for Superior Biology Services since 2000

    Home
    Journals
    Contact
    Posts
Cookie Use
We use cookies to ensure a smooth browsing experience. By continuing we assume you accept the use of cookies.
Learn More