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Cat. No.: RMLIF-10 (for 10μg)

Cat. No.: RMLIF-50 (for 50μg)

Cat. No.: RMLIF-200 (for 200μg)

 

Synonyms    

IDO; INDO; IDO-1


Purity    

>90% by SDS-PAGE; no detectable DNase and RNase


Biological Activity  

 >300U/μg


Physical Appearance    

Lyophilized (freeze-dried) powder


Formulation    

Lyophilized from a 0.2µm filtered solution in 10mM Tris-HCl (pH7.0 @ 25ºC), 500mM NaCl, 5% (w/v) Trehalose


Reconstitution    

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water by gentle pipetting or tapping to a concentration of 1.0mg/ml. Do not vortex. Stock solutions should be apportioned into working aliquots to avoid freeze-thaw cycles and stored at -80ºC. Further dilutions should be made in appropriate buffered solutions.


Endotoxin    

N.A.


Category    

Metabolic enzyme


Background    

Indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan

Only for research and not intended for treatment of humans or animals

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