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Human ADH1B and ALDH2 Alcohol Metabolism Genotyping Kit

Human ADH1B and ALDH2 Alcohol Metabolism Genotyping Kit

$55.00 - $395.00
When alcohol (ethanol) enters the human body, it is first converted into acetaldehyde by alcohol dehydrogenase (encoded by the ADH1 gene). Acetaldehyde is then further metabolized into acetic acid by aldehyde dehydrogenase (encoded by the ALDH2 gene). If ADH1 enzyme activity is low, ethanol cannot be efficiently converted and prolonged retention may damage the liver. Acetaldehyde dilates capillaries, which causes facial flushing. When acetaldehyde accumulates and cannot be further metabolized into acetic acid for elimination, it not only leads to persistent flushing but also increases the risk of nausea, disorientation, and other toxic symptoms. Therefore, the combined genotypes of ALDH2 and ADH1 determine the efficiency of alcohol metabolism and individual tolerance. Acetaldehyde accumulation is the direct cause of flushing and intoxication symptoms.
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Cat. No.: ADHIB-96 (for Human Alcohol Metabolism Genotyping Kit (ADH1B), 96T)

Cat. No.: ALDH2-96 (for Human Alcohol Metabolism Genotyping Kit (ALDH2), 96T)

Cat. No.: OSST-96 (for Oral Swab Sampling Tube (with Sample Preservation Solution), 96T)

 

Description

When alcohol (ethanol) enters the human body, it is first converted into acetaldehyde by alcohol dehydrogenase (encoded by the ADH1 gene). Acetaldehyde is then further metabolized into acetic acid by aldehyde dehydrogenase (encoded by the ALDH2 gene). If ADH1 enzyme activity is low, ethanol cannot be efficiently converted and prolonged retention may damage the liver.

Acetaldehyde dilates capillaries, which causes facial flushing. When acetaldehyde accumulates and cannot be further metabolized into acetic acid for elimination, it not only leads to persistent flushing but also increases the risk of nausea, disorientation, and other toxic symptoms.

Therefore, the combined genotypes of ALDH2 and ADH1 determine the efficiency of alcohol metabolism and individual tolerance. Acetaldehyde accumulation is the direct cause of flushing and intoxication symptoms.

 

Result Interpretation

    

Gene

  • ADH1B

Genotype

  • AA

Result

  • Wild type

Interpretation

  • Strong ability to metabolize ethanol into acetaldehyde.
 
  • GA
  • Heterozygous variant
  • Moderate ability to metabolize ethanol into acetaldehyde.
 
  • GG
  • Homozygous variant
  • Weak ability to metabolize ethanol into acetaldehyde.
  • ALDH2
  • GG
  • Wild type
  • Normal ALDH2 enzyme activity; strong alcohol metabolism capacity; no effect on nitroglycerin efficacy.
 
  • GA
  • Heterozygous variant
  • Reduced ALDH2 enzyme activity; weaker alcohol metabolism; may cause flushing, palpitations, and other discomfort after drinking; nitroglycerin efficacy may be affected.
 
  • AA
  • Homozygous variant
  • Deficient ALDH2 enzyme activity; extremely weak alcohol metabolism; strong adverse reactions after drinking; nitroglycerin efficacy significantly reduced.

Storage

  • Transport at room temperature.
  • For long-term storage, keep at 2–8 °C.

 

 

 

Only for research and not intended for treatment of humans or animals
 
 

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory

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