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Cat. No.: CAPE-0.2 (for 10mM×0.2ml)

Cat. No.: CAPE-5 (for 5mg)

Cat. No.: CAPE-25 (for 25mg)

Cat. No.: CAPE-100 (for 100mg)

Description

Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of the nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, showcasing antineoplastic, cytoprotective, and immunomodulating activities. CAPE, the phenethyl alcohol ester of caffeic acid, is a bioactive component found in honeybee hive propolis. Moreover, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells by activating p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha, leading to the subsequent induction of heme oxygenase-1 (HO-1).

Basic Information

• Aliases: CAPE; Phenylethyl Caffeate
• Source: Apis mellifera L.
• Compound type: Phenylpropanoids > Phenylpropanoic acids
• Chemical Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.31
• CAS Number: 104594-70-9
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 28.4 mg/mL (100 mM)
• Solution Preparation: Add 5mg to 1.76ml of DMSO, or add 2.84mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

Apoptosis; NF-κB; PI3K/Akt

In Vitro Study

Caffeic acid phenethyl ester effectively inhibits NF-κB activation triggered by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by impeding the translocation of the p65 subunit of NF-κB into the nucleus. Across various tumor cell lines, it demonstrates notable antiproliferative activity, with EC50 values of 1.76 μM, 3.16 μM, 13.7 μM, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma, and human lung A549 adenocarcinoma cell lines, respectively.

As a potent antioxidant, caffeic acid phenethyl ester exerts anti-apoptotic effects in cerebellar granule cells by inhibiting ROS formation and caspase activity. Additionally, it mitigates the pro-inflammatory phenotype of LPS-stimulated HSCs and inhibits LPS-induced sensitization of HSCs to fibrogenic cytokines by blocking NF-κB signaling.

In Vivo Study

In vivo studies demonstrate that Caffeic acid phenethyl ester (10 mg/kg, i.p.) effectively suppresses the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice models inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. Furthermore, Caffeic acid phenethyl ester (at doses of 5, 10, and 20 mg/kg) exhibits immunomodulatory effects in vivo, evidenced by reductions in thymus weight and/or cellularity of both thymus and spleen.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory