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Cat. No.: APGN-0.2 (for 10mM×0.2ml)

Cat. No.: APGN-25 (for 25mg)

Cat. No.: APGN-100 (for 100mg)

Description

Apigenin (4',5,7-Trihydroxyflavone) acts as a competitive inhibitor of CYP2C9 with a Ki value of 2 μM.

Basic Information

• Aliases: 4',5,7-Trihydroxyflavone; Apigenol; Natural Yellow 1
• Source: Arisaema heterophyllum Blume; Apium graveolens L.
• Compound type: Flavonoids > Flavones
• Chemical Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.24
• CAS Number: 520-36-5
• Purity: 98%, HPLC
• Solvent/Solubility: Water: <0.1 mg/ml (insoluble); DMSO: 100 mg/ml (370.04 mM)
• Solution Preparation: 5mg can be dissolved in 1.85ml DMSO, or 2.70mg can be dissolved in 1ml DMSO to prepare a 10mM solution.

Signaling Pathway

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In Vitro Study

Apigenin (4',5,7-Trihydroxyflavone) inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system, a purified, reconstituted enzyme system containing recombinant human CYP2C9, P450 reductase, cytochrome b5, and liposomes. Additionally, it inhibits cell proliferation, with growth inhibition rates (IR) of 38%, 71%, and 99% observed at concentrations of 20, 40, and 80 μM, respectively, on the 7th day. After exposure to Apigenin for 24 or 48 hours, the clone formation of SGC-7901 cells is suppressed in a dose- and time-dependent manner. The cloning efficiency at 80 μM is 9.8% and 5% after 24 and 48 hours of treatment, respectively, compared to 40.4% and 43.4% in the control group.

In Vivo Study

Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. At doses of 125 mg/kg and 250 mg/kg, apigenin alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury by inhibiting the release of serum aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK).

Clinical Trial

NCT03526081: Healthy, Not Applicable; NCT04114916: Cholesterol, Not Applicable.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory