Nucleic Acid Test - SBS Genetech - for Superior Biology Services since 2000

Human ADH1B and ALDH2 Alcohol Metabolism Genotyping Kit

When alcohol (ethanol) enters the human body, it is first converted into acetaldehyde by alcohol dehydrogenase (encoded by the ADH1 gene). Acetaldehyde is then further metabolized into acetic acid by aldehyde dehydrogenase (encoded by the ALDH2 gene). If ADH1 enzyme activity is low, ethanol cannot be efficiently converted and prolonged retention may damage the liver. Acetaldehyde dilates capillaries, which causes facial flushing. When acetaldehyde accumulates and cannot be further metabolized into acetic acid for elimination, it not only leads to persistent flushing but also increases the risk of nausea, disorientation, and other toxic symptoms. Therefore, the combined genotypes of ALDH2 and ADH1 determine the efficiency of alcohol metabolism and individual tolerance. Acetaldehyde accumulation is the direct cause of flushing and intoxication symptoms.