Lateral Flow System - SBS Genetech - for Superior Biology Services since 2000

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- Products
  All Products
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  Innovative Systems
  Nucleic Acid Related
  Enzymes
- POCT
  Integrated POCT Platform
  LAMP
  RPA
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  Lateral Flow System
  Freeze-Drying System
- About
  About SBS
  Solutions
  Achievements
  Legal Statement
- Contact

- Login

from China, for the World
for Superior Biology Services since 2000

Home
Products
All Products
Custom Services
Catalog Products
Innovative Systems
Nucleic Acid Related
Enzymes
POCT
Integrated POCT Platform
LAMP
RPA
CRISPR
DNA-Free Enzymes
Lateral Flow System
Freeze-Drying System
About
About SBS
Solutions
Achievements
Legal Statement
Contact
- Home
- Products
  All Products
  Custom Services
  Catalog Products
  Innovative Systems
  Nucleic Acid Related
  Enzymes
- POCT
  Integrated POCT Platform
  LAMP
  RPA
  CRISPR
  DNA-Free Enzymes
  Lateral Flow System
  Freeze-Drying System
- About
  About SBS
  Solutions
  Achievements
  Legal Statement
- Contact

- Login

dFnCas12a Nuclease

$500.00 - $2,120.00

sssLbCas12a Nuclease

sssLbCas12a (single-stranded DNA-specific LbCas12a) is a mutant engineered from wild-type LbCas12a endonuclease. Obtained via targeted engineering and screening, this mutant specifically recognizes target ssDNA while exhibiting extremely low activity for the recognition and cleavage of target dsDNA. Similar to the mechanism of action of wild-type LbCas12a, sssLbCas12a is crRNA-guided to recognize and cleave target ssDNA in a PAM-independent manner. In addition, recognition and binding to target ssDNA can activate the trans-cleavage activity of sssLbCas12a, degrading ssDNA probes present in the reaction system. Therefore, sssLbCas12a can be applied for rapid detection of target nucleic acids.

$500.00 - $2,120.00

cis-Only FnCas12a Nuclease

cis-Only FnCas12a is a mutant engineered from wild-type FnCas12a endonuclease. Through targeted engineering and screening, this mutant retains only cis-cleavage activity against target DNA sequences; no significant trans-cleavage activity can be detected for this enzyme, regardless of whether the target is dsDNA or ssDNA. Therefore, this enzyme can be used in applications sensitive to Cas12a trans-cleavage activity.

$500.00 - $2,120.00

enLbCas12a Nuclease

enLbCas12a (enhanced LbCas12a) is a high-activity LbCas12a mutant engineered from wild-type LbCas12a endonuclease. Sharing the same mechanism of action as wild-type LbCas12a, enLbCas12a is guided by crRNA to specifically recognize double-stranded DNA bearing the PAM sequence (5’-TTN-3’), resulting in double-stranded DNA breaks with sticky ends. Meanwhile, recognition and cleavage of single-stranded DNA targets by enLbCas12a are PAM-independent. Once enLbCas12a assembles into a ternary complex with crRNA and target DNA, it triggers cleavage of non-specific ssDNA sequences, degrading ssDNA present in the reaction system. Therefore, enLbCas12a can be applied not only for specific cleavage of DNA targets but also for rapid detection of target nucleic acids.

$500.00 - $2,120.00

GeCas12a2 Nuclease

GeCas12a2 nuclease was screened from environmental metagenomes rather than from a single isolated and purified known axenic strain. Its amino acid sequence shares 89% identity with SuCas12a2. Cas12a2 is a crRNA-guided endonuclease that targets RNA sequences, and the direct repeat (DR) sequence of its crRNA is largely consistent with that of Cas12a. Under the guidance of crRNA, GeCas12a2 assembles into a ternary complex together with crRNA and target ssRNA, enabling specific cleavage of the target ssRNA. Meanwhile, GeCas12a2 is activated to exert trans-cleavage activity toward unpaired ssDNA, ssRNA and dsDNA, indiscriminately degrading any ssDNA, ssRNA and dsDNA sequences present in the system. Unlike other Cas nucleases, which only perform trans-cleavage on ssDNA (e.g., Cas12a, Cas12b) or ssRNA (e.g., Cas13a) upon target activation, GeCas12a2 exhibits substantially stronger non-specific cleavage activity.

$500.00 - $2,120.00

FnCas12a Nuclease (Lyophilized)

FnCas12a (also known as Cpf1) nuclease is derived from the strain Francisella tularensis. FnCas12a is a crRNA-guided DNA endonuclease. In the presence of a PAM (TTN) sequence on the target double-stranded DNA, it specifically cleaves the target double-stranded DNA, inducing double-strand breaks with sticky ends. In contrast, the specific cleavage of single-stranded DNA targets by FnCas12a is PAM-independent. Once FnCas12a assembles into a ternary complex with crRNA and target DNA, it triggers collateral cleavage of non-specific single-stranded DNA (ssDNA), degrading any ssDNA sequences present in the reaction system. For this reason, FnCas12a can be applied for rapid detection of target nucleic acids.

$2,250.00 - $8,750.00

NativePure™ Recombinant Rat IL-7 (HEK293)

Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and also stimulates proliferation of B cells, T cells and NK cells. Furthermore, IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection. Rat IL-7 contains 129 amino acid residues and has three disulfide bonds. In addition, it has approximately 57% and 88% amino acid sequence identity with human and murine IL-7.

$445.00 - $4,000.00

NativePure™ Recombinant Mouse IL-7 (HEK293)

IL-7 is encoded by the IL7 gene in mouse and secreted by stromal cells in the red marrow and thymus. It signals through the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and common gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and it can stimulate proliferation of B cells, T cells and NK cells. Mouse IL-7 has approximately 65% and 88% amino acid sequence identity with human and rat IL-7 and both proteins exhibit cross-species activity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection.

$335.00 - $3,000.00

NativePure™ Recombinant Human IL-7 (HEK293)

Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and also stimulates proliferation of B cells, T cells and NK cells. Murine IL-7 has approximately 65% amino acid sequence identity with human IL-7 and both proteins exhibit cross-species activity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection.

$430.00 - $3,000.00

NativePure™ Recombinant Rat IL-5 (HEK293)

IL-5 is belonging to the cytokine family and the IL-5 gene is in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor, which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. Rat IL-5 is a 132-amino acid (115 in human, 133 in mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL-3 and GM-CSF), this glycoprotein in its active form is a homodimer.

$350.00 - $3,000.00

NativePure™ Recombinant Mouse IL-5 (HEK293)

IL-5 is belonging to the cytokine family and the IL-5 gene is in close proximity to the genes encoding IL-3, IL-4, and GM-CSF, which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. The cDNA for murine IL-5 encodes a signal peptide and a 113 amino acid mature protein. Mature murine IL-5 shares 70%, 94%, 58%, 66%, 59% and 63% a.a. sequence identity with human, rat, canine, equine, feline and porcine IL5, respectively. It shows cross-reactivity with human IL5 receptor.

$330.00 - $2,700.00

NativePure™ Recombinant Human IL-5 (HEK293)

The IL-5 gene is located on chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocytemacrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL-3 and GM-CSF), this glycoprotein in its active form is a homodimer.

$330.00 - $2,700.00

NativePure™ Recombinant Rat IL-3β (HEK293)

IL-3 is a type of biological signal which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. The protein acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. It exerts its biological activities through binding to interleukin-3 receptors included α and β subunits. The Mouse IL-3 is different from human IL-3 and contains 140 amino acids residues. Specifically, mouse and human IL-3 share low homology and have not cross species activity.

$385.00 - $3,000.00

NativePure™ Recombinant Mouse IL-3 (HEK293)

IL-3 is a type of biological signal which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. The protein acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. It exerts its biological activities through binding to interleukin-3 receptors included α and β subunits. The Mouse IL-3 is different from human IL-3 and contains 140 amino acids residues. Specifically, mouse and human IL-3 share low homology and have not cross species activity.

$400.00 - $3,500.00

NativePure™ Recombinant Human IL-3 (HEK293)

Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. The protein acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. The human IL-3 reported to be a monomer, as it is known, contains 133 amino acids residues which is a single non-glycosylated polypeptide. Specifically, human and murine IL-3 share low homology and it does not show activity on murine cells.

$300.00 - $2,350.00

NativePure™ Recombinant Rat IL-2 (HEK293)

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions which are essential for the immune response. The receptor for IL-2 consists of three subunits (55kDa IL2Rα, 75kDa IL2Rβ, 64kDa common gamma chain γc/IL2Rγ) that are present on the cell surface in varying preformed complexes. Recombinant rat IL-2 is a 15.3kDa protein and it shares about 82%, 66%, 66%, 60% and 54% amino acid sequence identity with mouse, human, rhesus macaque, pig and equus caballus IL-2, respectively.

$265.00 - $1,750.00

NativePure™ Recombinant Mouse IL-2 (HEK293)

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. The receptor for IL-2 consists of three subunits (55kDa IL-2Rα, 75kDa IL-2Rβ, 64kDa common gamma chain γc/IL2Rγ) that are present on the cell surface in varying preformed complexes. Mature mouse IL-2 shares 56% and 73% amino acid sequence identity with human and rat IL-2 respectively. Mouse and human IL-2 exhibit cross-species activity. Mouse IL-2 has a specific N-terminal region that contains a poly glutamine (contain 12 glutamines) stretch.

$285.00 - $2,500.00

NativePure™ Recombinant Human IL-2 (HEK293)

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. The receptor for IL-2 consists of three subunits (55kDa IL-2Rα, 75kDa IL-2Rβ, and 64kDa common gamma chain γc/IL-2Rγ) that are present on the cell surface in varying preformed complexes. Mature human IL-2 shares 56% and 66% amino acid sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity.

$300.00 - $1,850.00

NativePure™ Recombinant Rat IL-6 (HEK293)

Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN. Function: TGF beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Tissue specificity: TGF beta 1 is highly expressed in bone.The mature mouse TGF-β1 shares 99% and 100% aa sequence identity with human and rat, respectively. A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly.

$365.00 - $3,150.00

NativePure™ Recombinant Mouse IL-6 (HEK293)

Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN. Function: TGF beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Tissue specificity: TGF beta 1 is highly expressed in bone.The mature mouse TGF-β1 shares 99% and 100% aa sequence identity with human and rat, respectively. A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly.

$335.00 - $2,900.00

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