Description

The T2T genome (Telomere-to-Telomere), also known as the complete genome assembly from end to end, represents a more comprehensive genome. The T2T genome is primarily achieved through the use of multiple sequencing platforms, high-depth sequencing, and various software methods to obtain a high-quality genome with telomeres and centromeres that is gap-free or gap-less. Telomeres are specialized structures at the ends of eukaryotic chromosomes, composed of DNA repeat sequences and specific binding proteins. In higher organisms, centromeres are formed by thousands of tandemly repeated units. These highly complex repeat regions are major challenges in third-generation sequencing and assembly, and are the main focus of T2T genome efforts. Constructing the T2T genome will further facilitate the analysis of complex regions in species genomes, especially the "dark regions" that were difficult to decipher in the past, providing important foundational information for in-depth species research.

Technical Features

• Ability to obtain a high-quality genome with high accuracy, high continuity, and high completeness from telomere to telomere
• Overcomes the challenges of assembling centromeres and highly repetitive regions
• Facilitates the exploration of chromosome origins, domestication, and identification of key sex-determining genes