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- Products
- All Products
- Custom Services
- Catalog Products
- Innovative Systems
- Nucleic Acid Related
- Natural Compounds
- Enzymes
- POCT
- 6 POCT Platforms
- LAMP
- RPA
- CRISPR
- Freeze-Drying System
- Lateral Flow System
- DNA-Free Enzymes
- Pathogen Detection
- About
- About SBS
- Achievements
- Ecosystem
- Legal Statement
from China, for the World
for Superior Biology Services since 2000
- Products
- All Products
- Custom Services
- Catalog Products
- Innovative Systems
- Nucleic Acid Related
- Natural Compounds
- Enzymes
- POCT
- 6 POCT Platforms
- LAMP
- RPA
- CRISPR
- Freeze-Drying System
- Lateral Flow System
- DNA-Free Enzymes
- Pathogen Detection
- About
- About SBS
- Achievements
- Ecosystem
- Legal Statement
- …
- Products
- All Products
- Custom Services
- Catalog Products
- Innovative Systems
- Nucleic Acid Related
- Natural Compounds
- Enzymes
- POCT
- 6 POCT Platforms
- LAMP
- RPA
- CRISPR
- Freeze-Drying System
- Lateral Flow System
- DNA-Free Enzymes
- Pathogen Detection
- About
- About SBS
- Achievements
- Ecosystem
- Legal Statement
Oligonucleotides
Backed by 20+ years of expertise, SBS Genetech continues to lead innovation in oligonucleotide synthesis and applications
Over Two Decades of Excellence in Oligonucleotide Synthesis
With more than 20 years of dedicated expertise, SBS Genetech stands at the forefront of custom oligonucleotide synthesis, serving scientists, clinicians, and industry innovators worldwide. Our integrated capabilities span from research‑grade probes to clinical‑grade therapeutic candidates, enabling us to meet the needs of molecular biology, diagnostics, drug discovery, and synthetic biology.
Through advanced automated platforms, rigorous quality control, and a deep understanding of both chemistry and biology, we deliver oligonucleotides with exceptional purity, yield, and reproducibility — from small‑scale R&D batches to large‑scale GMP‑compliant production.
We not only provide standard primers and probes but also engineer complexly modified oligonucleotides, tailored to specific scientific and industrial applications. This combination of technical depth, customization, and reliability makes SBS Genetech a trusted partner across the life sciences.
Gene Regulation & Therapeutics
- Antisense Oligonucleotides (ASOs) — For targeted mRNA degradation or splicing modulation
- siRNA / miRNA / saRNA — RNA interference or gene activation tools for preclinical and clinical research
- Antigene Oligonucleotides — DNA‑binding sequences to block transcription
- Ribozymes / DNAzymes — Catalytically active nucleic acids for selective cleavage
- Transcription Factor Decoys — Competitive inhibitors of transcription factor binding
- Splice‑Switching Oligos — Redirecting alternative splicing patterns
- CpG‑ODNs — Immunostimulatory agents in vaccine development
Molecular Diagnostics & Detection
- qPCR / Digital PCR Probes — TaqMan, MGB, molecular beacons, and other formats
- Fluorescent In Situ Hybridization (FISH) Probes — For chromosomal or spatial transcriptomics studies
- DNA/RNA Barcodes & Molecular Tags — High‑throughput sequencing and sample tracking
- Oligo(dT) Primers — mRNA isolation via poly(A) tail capture
- Padlock Probes — Enabling rolling circle amplification for ultra‑specific detection
- CRISPR Guide RNAs — Custom single‑guide RNAs for gene editing and CRISPR‑based diagnostics
- Microarray Probes — Gene expression profiling or SNP detection
Chemical Biology & Drug Discovery
- DNA‑Encoded Library (DEL) Oligos — Tags for screening small‑molecule libraries
- Combinatorial Trimer Primers — Introduce diversity in directed evolution projects
- Chemically Modified Oligos — Including fluorophores, quenchers, biotin, azide/alkyne groups for conjugation or click chemistry
- Photo‑Crosslinking Oligos — To study biomolecular interactions
- Nucleic Acid Nanostructures — DNA origami and programmable nanodevices
Synthetic Biology & Engineering
- Genetic Circuit Components — Promoters, switches, insulators, and regulatory elements
- Toehold Switches — RNA‑based synthetic sensors for control of gene expression
- Aptamer‑Based Biosensors — Coupled with nanomaterials for rapid, field‑deployable detection
- Custom Regulatory Oligos — Engineered for tunable gene control in living systems
Epigenetics & Genome Research
- Methylation‑Specific Oligos — For detecting DNA methylation and hydroxymethylation
- Bisulfite Sequencing Primers — For base‑resolution epigenetic mapping
- Chromatin Interaction Probes — For 3D genome architecture studies (Hi‑C, Capture‑C)
Clinical & Translational Applications
- Diagnostic Kit Oligos — For infectious disease, oncology, and genetic disorder detection
- Companion Diagnostic Oligos — Matched to targeted therapeutics
- Therapeutic Monitoring Probes — For assessing treatment efficacy via nucleic acid biomarkers
Oligonucleotide Synthesis Services
miRNA Primer Synthesis
Bisulfite sequencing PCR (BSP) Primer Synthesis
Methylation‑specific PCR (MSP) Primer Synthesis
NGS Multiplex Oligos Synthesis
NGS Blockers Synthesis
NGS Adapters Synthesis
NGS Panel Synthesis
Light-Activated NPOM-dt Modified Oligonucleotide
IVD Probes & Primers (qPCR, NGS, STR, RPA, LAMP, FISH Series)
16S/18S FISH Probe Design & Synthesis
circRNA Overexpression Plasmid Construction
DEL (DNA Encoded Compound Library) Primers
Oligo dT Synthesis
SELEX Aptamer Library Screening
Custom DNA Oligonucleotides
Circular RNA Synthesis
Custom Circular Single-Stranded DNA
Probes for Quantitative, Real-time PCR
Double-Quenched Probes
DNA Encoding Library Synthesis ServiceSelected Published Papers
SBS Genetech supplies high-quality oligonucleotides, empowering researchers to publish over 800 papers in prestigious journals such as Nucleic Acids Research, Biosensors and Bioelectronics, and Blood
Nucleic Acids Research | 01 Jan 2004 | DOI: https://doi.org/10.1093/nar/gnh100
All the DNA sequences were custom synthesized from SBS Genetech Co. Ltd. (Beijing, China). These include the DRE element sequence (ACCGAC), 5′-NH 2 -GATATACT ACCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTGTACTCAAG-5′; the DRE element sequence (GCCGAC), 5′-NH 2 -GATATACT GCCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGACGGCTGTACTCAAG-5′; the ERE element (GCCGCC), 5′-NH 2 -CGCAGACATA GCCGCC ATTT-3′, and its complementary ssDNA, 3′-GCGTCTGTATCGGCGGTAAA-5′; the mutant DRE element sequence (ACCGAG), 5′-NH 2 -GATATACT ACCGAG ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTCTACTCAAG-5′ (the element sequences are underlined).
Blood | 01 March 2004 | DOI: https://doi.org/10.1182/blood-2003-08-2828
To assess Hsp70L1 expression in DCs, 6-day DCs generated from human peripheral monocytes were stimulated at 5 × 105 cells/mL for 8 hours with 1 μg/mL lipopolysaccharide (LPS) (Sigma), 30 μg/mL CpG oligonucleotides (5′-TCGTCGTTCCCCCCCCCC-CC-3′; SBS Genetech, Beijing, China)
Nucleic Acids Research | 30 Aug 2008 | DOI: https://doi.org/10.1093/nar/gkn543
HPLC purified oligonucleotides were procured from SBS Genetech, China. The concentrations of these oligonucleotides were calculated by extrapolation of tabulated values of the monomer bases and dimers at 25°C using procedures reported earlier
Biosensors and Bioelectronics | 31 Oct 2014 | DOI: https://doi.org/10.1016/j.bios.2014.10.055
Deoxyribonucleoside 5′-triphosphates (dNTPs) mixture and all oligonucleotides as depicted in Table S1 of Supporting information were purchased from SBS Genetech. Co. Ltd. (China).
Sensors and Actuators B: Chemical | 10 June 2015 | DOI: https://doi.org/10.1016/j.snb.2015.05.089
Blood sera and aptamer were acquired from SBS Genetech Co. Ltd. (Beijing, China) and has the following sequences: 5′-TCTCTCAGTCCGTGGTAGGGCAGGGTTGGGGTGACT-3′......
Biosensors and Bioelectronics | 16 Nov 2016 | DOI: https://doi.org/10.1016/j.bios.2016.11.019
Aptamer was obtained from SBS Genetech Co., Ltd. (Beijing, China), and the sequence was: 5′-CAG GCT ACG GCA CGT AGA GCA TCA CCA TGA TCC
Biosensors and Bioelectronics | 17 Mar 2017 | DOI: https://doi.org/10.1016/j.bios.2017.03.014
Aptamer strands were obtained from SBS Genetech Co. Ltd (Beijing, China).
International Journal of Biological Macromolecules | 9 June 2023 | DOI: https://doi.org/10.1016/j.ijbiomac.2023.125211
The oligonucleotides employed in this experiment were procured from Beijing SBS Genetech Co. Ltd. (China). The sequences of the reporter and three aptamers were obtained in accordance with their relevant references [36,37], while crRNA and activator DNA sequences were designed in our laboratory.
Biomedicine & Pharmacotherapy | 19 March 2024 | DOI: https://doi.org/10.1016/j.biopha.2024.116465
The aptamer used (sequence: 5′-GCCCGCCGTGGCTGGGTCTTCCTTGGTCGGTCTACAAAAAAAAAA-SH-3′) was obtained from SBS Genetech Co. Ltd.
Sensors and Actuators B: Chemical | 28 November 2024 | DOI: https://doi.org/10.1016/j.snb.2024.137015
The oligonucleotides utilised in this study were obtained from Beijing SBS Genetech Co. Ltd. (Beijing, China). The sequences of the dsDNA, reporter, and aptamers were obtained following their relevant references while gRNA...
Sensors and Actuators Reports | 24 March 2025 | DOI: https://doi.org/10.1016/j.snr.2025.100318
Nucleotide sequences were synthesized by Beijing SBS Genetech Co., Ltd.
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from China, for the World
for Superior Biology Services since 2000

