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tech@sbsbio.com
Beijing SBS Genetech Co.,Ltd.
Beijing SBS Genetech Co.,Ltd.

from China, for the World

for Superior Biology Services since 2000

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  • …  
    • Products 
      • All Products
      • Custom Services
      • Catalog Products
      • Innovative Systems
      • Nucleic Acid Related
      • Natural Compounds
      • Enzymes
    • POCT 
      • 6 POCT Platforms
      • LAMP
      • RPA
      • CRISPR
      • Freeze-Drying System
      • Lateral Flow System
      • DNA-Free Enzymes
      • Pathogen Detection
    • Synbio 
      • Synthetic Biology
      • NMN
      • SBS Insights
    • About 
      • About SBS
      • Achievements
      • Ecosystem
      • Legal Statement
    • Contact
    • Login
tech@sbsbio.com
Beijing SBS Genetech Co.,Ltd.
Beijing SBS Genetech Co.,Ltd.

from China, for the World

for Superior Biology Services since 2000

  • Products 
    • All Products
    • Custom Services
    • Catalog Products
    • Innovative Systems
    • Nucleic Acid Related
    • Natural Compounds
    • Enzymes
  • POCT 
    • 6 POCT Platforms
    • LAMP
    • RPA
    • CRISPR
    • Freeze-Drying System
    • Lateral Flow System
    • DNA-Free Enzymes
    • Pathogen Detection
  • Synbio 
    • Synthetic Biology
    • NMN
    • SBS Insights
  • About 
    • About SBS
    • Achievements
    • Ecosystem
    • Legal Statement
  • Contact
  • …  
    • Products 
      • All Products
      • Custom Services
      • Catalog Products
      • Innovative Systems
      • Nucleic Acid Related
      • Natural Compounds
      • Enzymes
    • POCT 
      • 6 POCT Platforms
      • LAMP
      • RPA
      • CRISPR
      • Freeze-Drying System
      • Lateral Flow System
      • DNA-Free Enzymes
      • Pathogen Detection
    • Synbio 
      • Synthetic Biology
      • NMN
      • SBS Insights
    • About 
      • About SBS
      • Achievements
      • Ecosystem
      • Legal Statement
    • Contact
    • Login
Beijing SBS Genetech Co.,Ltd.
  • Oligonucleotides

    Backed by 20+ years of expertise, SBS Genetech continues to lead innovation in oligonucleotide synthesis and applications

  • Over Two Decades of Excellence in Oligonucleotide Synthesis

    With more than 20 years of dedicated expertise, SBS Genetech stands at the forefront of custom oligonucleotide synthesis, serving scientists, clinicians, and industry innovators worldwide. Our integrated capabilities span from research‑grade probes to clinical‑grade therapeutic candidates, enabling us to meet the needs of molecular biology, diagnostics, drug discovery, and synthetic biology.

    Through advanced automated platforms, rigorous quality control, and a deep understanding of both chemistry and biology, we deliver oligonucleotides with exceptional purity, yield, and reproducibility — from small‑scale R&D batches to large‑scale GMP‑compliant production.

    We not only provide standard primers and probes but also engineer complexly modified oligonucleotides, tailored to specific scientific and industrial applications. This combination of technical depth, customization, and reliability makes SBS Genetech a trusted partner across the life sciences.

    Gene Regulation & Therapeutics
    • Antisense Oligonucleotides (ASOs) — For targeted mRNA degradation or splicing modulation
    • siRNA / miRNA / saRNA — RNA interference or gene activation tools for preclinical and clinical research
    • Antigene Oligonucleotides — DNA‑binding sequences to block transcription
    • Ribozymes / DNAzymes — Catalytically active nucleic acids for selective cleavage
    • Transcription Factor Decoys — Competitive inhibitors of transcription factor binding
    • Splice‑Switching Oligos — Redirecting alternative splicing patterns
    • CpG‑ODNs — Immunostimulatory agents in vaccine development
    Molecular Diagnostics & Detection
    • qPCR / Digital PCR Probes — TaqMan, MGB, molecular beacons, and other formats
    • Fluorescent In Situ Hybridization (FISH) Probes — For chromosomal or spatial transcriptomics studies
    • DNA/RNA Barcodes & Molecular Tags — High‑throughput sequencing and sample tracking
    • Oligo(dT) Primers — mRNA isolation via poly(A) tail capture
    • Padlock Probes — Enabling rolling circle amplification for ultra‑specific detection
    • CRISPR Guide RNAs — Custom single‑guide RNAs for gene editing and CRISPR‑based diagnostics
    • Microarray Probes — Gene expression profiling or SNP detection
    Chemical Biology & Drug Discovery
    • DNA‑Encoded Library (DEL) Oligos — Tags for screening small‑molecule libraries
    • Combinatorial Trimer Primers — Introduce diversity in directed evolution projects
    • Chemically Modified Oligos — Including fluorophores, quenchers, biotin, azide/alkyne groups for conjugation or click chemistry
    • Photo‑Crosslinking Oligos — To study biomolecular interactions
    • Nucleic Acid Nanostructures — DNA origami and programmable nanodevices
    Synthetic Biology & Engineering
    • Genetic Circuit Components — Promoters, switches, insulators, and regulatory elements
    • Toehold Switches — RNA‑based synthetic sensors for control of gene expression
    • Aptamer‑Based Biosensors — Coupled with nanomaterials for rapid, field‑deployable detection
    • Custom Regulatory Oligos — Engineered for tunable gene control in living systems

    Epigenetics & Genome Research
    • Methylation‑Specific Oligos — For detecting DNA methylation and hydroxymethylation
    • Bisulfite Sequencing Primers — For base‑resolution epigenetic mapping
    • Chromatin Interaction Probes — For 3D genome architecture studies (Hi‑C, Capture‑C)
    Clinical & Translational Applications
    • Diagnostic Kit Oligos — For infectious disease, oncology, and genetic disorder detection
    • Companion Diagnostic Oligos — Matched to targeted therapeutics
    • Therapeutic Monitoring Probes — For assessing treatment efficacy via nucleic acid biomarkers
  • Oligonucleotide Synthesis Services

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    miRNA Primer Synthesis
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    Bisulfite sequencing PCR (BSP) Primer Synthesis
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    Methylation‑specific PCR (MSP) Primer Synthesis
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    NGS Multiplex Oligos Synthesis
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    NGS Blockers Synthesis
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    NGS Adapters Synthesis
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    NGS Panel Synthesis
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    Light-Activated NPOM-dt Modified Oligonucleotide
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    IVD Probes & Primers (qPCR, NGS, STR, RPA, LAMP, FISH Series)
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    16S/18S FISH Probe Design & Synthesis
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    circRNA Overexpression Plasmid Construction
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    DEL (DNA Encoded Compound Library) Primers
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    Oligo dT Synthesis
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    SELEX Aptamer Library Screening
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    Custom DNA Oligonucleotides
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    Circular RNA Synthesis
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    Custom Circular Single-Stranded DNA
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    Probes for Quantitative, Real-time PCR
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    Double-Quenched Probes
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    DNA Encoding Library Synthesis Service
  • Selected Published Papers

    SBS Genetech supplies high-quality oligonucleotides, empowering researchers to publish over 800 papers in prestigious journals such as Nucleic Acids Research, Biosensors and Bioelectronics, and Blood

    Measuring specific interaction of transcription factor ZmDREB1A with its DNA responsive element at the molecular level

    Nucleic Acids Research | 01 Jan 2004 | DOI: https://doi.org/10.1093/nar/gnh100

    All the DNA sequences were custom synthesized from SBS Genetech Co. Ltd. (Beijing, China). These include the DRE element sequence (ACCGAC), 5′-NH 2 -GATATACT ACCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTGTACTCAAG-5′; the DRE element sequence (GCCGAC), 5′-NH 2 -GATATACT GCCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGACGGCTGTACTCAAG-5′; the ERE element (GCCGCC), 5′-NH 2 -CGCAGACATA GCCGCC ATTT-3′, and its complementary ssDNA, 3′-GCGTCTGTATCGGCGGTAAA-5′; the mutant DRE element sequence (ACCGAG), 5′-NH 2 -GATATACT ACCGAG ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTCTACTCAAG-5′ (the element sequences are underlined).

    Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant

    Blood | 01 March 2004 | DOI: https://doi.org/10.1182/blood-2003-08-2828

    To assess Hsp70L1 expression in DCs, 6-day DCs generated from human peripheral monocytes were stimulated at 5 × 105 cells/mL for 8 hours with 1 μg/mL lipopolysaccharide (LPS) (Sigma), 30 μg/mL CpG oligonucleotides (5′-TCGTCGTTCCCCCCCCCC-CC-3′; SBS Genetech, Beijing, China)

    A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes

    Nucleic Acids Research | 30 Aug 2008 | DOI: https://doi.org/10.1093/nar/gkn543

    HPLC purified oligonucleotides were procured from SBS Genetech, China. The concentrations of these oligonucleotides were calculated by extrapolation of tabulated values of the monomer bases and dimers at 25°C using procedures reported earlier

    Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation

    Biosensors and Bioelectronics | 31 Oct 2014 | DOI: https://doi.org/10.1016/j.bios.2014.10.055

    Deoxyribonucleoside 5′-triphosphates (dNTPs) mixture and all oligonucleotides as depicted in Table S1 of Supporting information were purchased from SBS Genetech. Co. Ltd. (China).

    Electrochemical aptasensor based on one-step synthesis of Cu2O@aptamer nanospheres for sensitive thrombin detection

    Sensors and Actuators B: Chemical | 10 June 2015 | DOI: https://doi.org/10.1016/j.snb.2015.05.089

    Blood sera and aptamer were acquired from SBS Genetech Co. Ltd. (Beijing, China) and has the following sequences: 5′-TCTCTCAGTCCGTGGTAGGGCAGGGTTGGGGTGACT-3′......

    Carbon-based nanocomposites with aptamer-templated silver nanoclusters for the highly sensitive and selective detection of platelet-derived growth factor

    Biosensors and Bioelectronics | 16 Nov 2016 | DOI: https://doi.org/10.1016/j.bios.2016.11.019

    Aptamer was obtained from SBS Genetech Co., Ltd. (Beijing, China), and the sequence was: 5′-CAG GCT ACG GCA CGT AGA GCA TCA CCA TGA TCC

    Fe(III)-based metal–organic framework-derived core–shell nanostructure: Sensitive electrochemical platform for high trace determination of heavy metal ions

    Biosensors and Bioelectronics | 17 Mar 2017 | DOI: https://doi.org/10.1016/j.bios.2017.03.014

    Aptamer strands were obtained from SBS Genetech Co. Ltd (Beijing, China).

    A CRISPR/Cas12a-based fluorescence aptasensor for the rapid and sensitive detection of ampicillin

    International Journal of Biological Macromolecules | 9 June 2023 | DOI: https://doi.org/10.1016/j.ijbiomac.2023.125211

    The oligonucleotides employed in this experiment were procured from Beijing SBS Genetech Co. Ltd. (China). The sequences of the reporter and three aptamers were obtained in accordance with their relevant references [36,37], while crRNA and activator DNA sequences were designed in our laboratory.

    Smart co-delivery of plasmid DNA and doxorubicin using MCM-chitosan-PEG polymerization functionalized with MUC-1 aptamer against breast cancer

    Biomedicine & Pharmacotherapy | 19 March 2024 | DOI: https://doi.org/10.1016/j.biopha.2024.116465

    The aptamer used (sequence: 5′-GCCCGCCGTGGCTGGGTCTTCCTTGGTCGGTCTACAAAAAAAAAA-SH-3′) was obtained from SBS Genetech Co. Ltd.

    Exploring aptamer-aTF sandwich and CRISPR-Cas12a methods for sensitive L-lactate biosensing in human serum and saliva

    Sensors and Actuators B: Chemical | 28 November 2024 | DOI: https://doi.org/10.1016/j.snb.2024.137015

    The oligonucleotides utilised in this study were obtained from Beijing SBS Genetech Co. Ltd. (Beijing, China). The sequences of the dsDNA, reporter, and aptamers were obtained following their relevant references while gRNA...

    Nucleic acid-free aptamer-CRISPR/Cas14 biosensor for prosthetic joint infection rapid detection

    Sensors and Actuators Reports | 24 March 2025 | DOI: https://doi.org/10.1016/j.snr.2025.100318

    Nucleotide sequences were synthesized by Beijing SBS Genetech Co., Ltd.

  • Contact

    For more information, please fill out the provided form or contact us directly by E-mail

    tech@sbsbio.com

SBS Genetech © Copyright 2000-2026

from China, for the World

for Superior Biology Services since 2000

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