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Cat. No.: rhCOL7-1-10 (for 10KD~, 10g)

Description

Type XVII collagen (COL17) is a transmembrane protein found in the epidermal basal layer, crucial for maintaining tight connections between the epidermis and dermis. It promotes epidermal turnover and stabilizes the basement membrane, thereby supporting anti-aging and repair processes from the basement membrane zone. Evidence suggests that the hydrolysis of COL17 can cause follicular miniaturization, ultimately leading to hair loss. Due to its unique physiological functions, COL17 shows promising potential in delaying and treating hair loss.

This product is recombinant humanized Type XVII collagen, derived from microorganisms. It boasts excellent water solubility, stability, hydrophilicity, and moisturizing properties. Utilizing the Pichia pastoris fermentation process, the product ensures lower endotoxin levels and greater safety.

Specifications

Product Grade Molecular biology grade, sterile lyophilized

CAS No. 9064‑67‑9

Source Species Microbial

Gene Origin Human

Product Specifications 50 g/bag, 100 g/bag, 1 kg/bag; in addition to standard packaging, customization is available according to customer requirements, with bulk packaging up to the 10 kg level.

Molecular Weight ~10 kDa

pI 7.54

Solubility Soluble in water at 100 g/L; after standing for 24 h, the solution remains clear and free of suspended particles. Suitable for short‑term transport and storage at room temperature. For long‑term storage, keep sealed at –20 °C.

Storage Conditions Store at –20 °C or below upon receipt.

Shelf Life At least 1 year when stored at –20 °C or below.

Applications Type XVI collagen is a transmembrane protein located in the epidermal basement membrane zone. It plays a role in maintaining tight connections between the epidermis and dermis, promoting epidermal turnover, and stabilizing the basement membrane, thereby contributing to anti‑aging repair from the basement membrane zone. Evidence indicates that hydrolysis of COL17 can cause miniaturization of hair follicles, ultimately leading to hair loss. Due to its unique physiological functions, COL17 has promising application prospects in delaying and treating hair loss.

Quality Specifications

Appearance White or off‑white sponge‑like lyophilized powder

Electrophoretic Purity

90% (SDS‑PAGE)

Protein Content

90% (Lowry method)

Moisture < 10%

Endotoxin < 0.5 EU/mg (LAL test)

Nucleic Acid Residue < 1 ppm

Microbiological Limits

• Total bacterial count: < 100 CFU/g

• Total fungal count: < 10 CFU/g

Heavy Metals

• Total residual heavy metals (Pb): < 10 ppm

• Arsenic (As): < 1 ppm

• Mercury (Hg): < 2 ppm

• Lead (Pb): < 5 ppm

• Chromium (Cr): < 5 ppm

• Cadmium (Cd): < 2 ppm

Pathogen Testing

• Escherichia coli: Not detected

• Staphylococcus aureus: Not detected

• Pseudomonas aeruginosa: Not detected

Related: Recombinant Humanized Type III Collagen