for Superior Biology Services
for Superior Biology Services
All products have special prices for bulk purchase, please contact us for more details if required.
Cat. No.: FPG-800 (for 800U)
Cat. No.: FPG-4k (for 4KU)
Fpg (formamidopyrimidine [fapy]-DNA glycosylase) (also known as 8-oxoguanine DNA glycosylase), has both N-terminal glycosylase activity and AP lyase activity. N-terminal glycosylase activity can cleave the damaged purine base on double-stranded DNA to produce an apurinic (AP site). AP lyase activity can cleave 3' or 5' to the AP site thereby removing the AP site and leaving a 1 base gap. The damaged bases recognized and removed by Fpg include 7, 8-dihydro-8-oxoguanine (8-oxoguanine), 8-oxoadenine, fapy-guanine, methy-fapy-guanine, fapy-adenine, aflatoxin B1-fapy-guanine, 5-hydroxy-cytosine, and 5-hydroxy-uracil.
One unit is defined as the amount of enzyme required to cleave 34 bp oligonucleotide double strand containing a single 8-oxoguanine paired with cytosine in 1 pmol within 1 hour in a 10 μl reaction system at 37°C.
Fpg (8 U/μl): 100 μl/500 μl
10X Fpg Reaction Buffer: 1 ml/1 ml×2
The minimum shelf life is 2 years at -20°C. Avoid repeated freezing and thawing.
Related: Tth MutS Protein, Tth MutL Protein
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