Description

Unlock the potential of gene regulation with Antisense Oligonucleotides (ASOs). These remarkable single-stranded DNA or RNA sequences, spanning 15-25 nucleotides, precisely target and pair with complementary genes. By skillfully obstructing gene transcription or translation, ASOs pave the way for advanced gene therapy. Their unparalleled advantages, including exceptional specificity, efficiency, and low toxicity, propel groundbreaking advancements in the field.

In the realm of gene-targeted therapeutic drugs, ASOs have emerged as game-changers. However, natural ASOs encounter hurdles such as degradation, limited specificity, and unwanted side effects. To overcome these challenges, our therapeutic ASOs are meticulously engineered with specific chemical modifications. These modifications bolster stability within the body, amplify specificity, and mitigate toxicity concerns.

Impeccable quality is our commitment. Our provided ASOs strictly adhere to rigorous QC testing standards, including comprehensive HPLC purity analysis. This stringent approach guarantees the delivery of ASO products of the highest caliber, empowering your research endeavors.

Features

• Manufacturing Capability: Our synthesis capabilities range from µg to g scale, catering to your needs from research-grade to manufacturing-grade requirements.
• Fast Delivery: With flexible project scheduling, we ensure quick turnaround times for timely delivery.
• Strict Quality Control: Our products adhere to strict quality control measures.
• Quality Analysis: We utilize HPLC and LC-Mass analysis, offering endotoxin and bioburden detection for cellular experiments.
• Expertise and Professionalism: Our team of nucleic acid synthesis experts provides specialized technical support.
• High Customization: We offer a wide range of modification options and flexible synthesis specifications to meet your specific needs.

Experience the power of our services, combining manufacturing capabilities, fast delivery, rigorous quality control, advanced analysis techniques, expert knowledge, and high customization options. Partner with us to unlock the full potential of nucleic acid synthesis and advance your research and manufacturing endeavors.

Service Details

• Yield: Research-grade (ug-mg), Manufacturing-grade (g)
• Purification Method: HPLC
• Modification Types: PTO, 2′-F, 2′-OME, 2′-MOE, LNA, Cholesterol, GalNAc, etc.

Deliverables

• Powder delivery, packaging according to customer requirements
• Certificate of Analysis (COA)

Related: Probes for Quantitative, Real-time PCR, Molecular Beacons, Oligonucleotide Conjugates

Learn More

Major antisense oligonucleotide (ASO) drugs along with their CAS numbers and modification types:

1. Inotersen (Trade name: Tegsedi)

   • CAS number: 1492984-65-2

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl (MOE) modifications, enhancing stability and reducing nuclease degradation.

2. Eplontersen

   • CAS number: 1637600-16-8

   • Modifications: Same nucleotide sequence as Inotersen, integrated with GalNAc delivery system (N-Acetylgalactosamine modification) to improve efficacy and reduce dosage frequency.

3. Mipomersen (Trade name: Kynamro)

   • CAS number: 629167-92-6

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications to increase RNA-binding capacity and stability.

4. Volanesorsen (Trade name: Waylivra)

   • CAS number: 915430-78-3

   • Modifications: Second-generation 2'-O-Methoxyethyl (2'-MOE) modifications for improved solubility and RNA targeting specificity.

5. Givosiran (Trade name: Givlaari)

   • CAS number: 1639325-43-1

   • Modifications: Double-stranded small interfering RNA (siRNA) drug with phosphate backbone modifications to enhance stability and reduce immunogenicity.

6. Nusinersen (Trade name: Spinraza)

   • CAS number: 1258984-36-9

   • Modifications: 2'-O-Methoxyethyl (MOE) modifications and phosphorothioate backbone, optimizing RNA splicing and improving stability.

7. Fomivirsen (Trade name: Vitravene)

   • CAS number: 155051-26-6

   • Modifications: Phosphorothioate backbone for enhanced stability and reduced degradation.

8. Golodirsen (Trade name: Vyondys 53)

   • CAS number: 1922968-73-7

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications for exon skipping.

9. Eteplirsen (Trade name: Exondys 51)

   • CAS number: 1173755-55-9

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications for exon skipping.

10. Tofersen (Trade name: Qalsody)

    • CAS number: 1633725-16-7

    • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications to lower SOD1 protein levels.

 

SBS Genetech is recognized as one of the global major leading industry players in Oligonucleotide Synthesis by third-party market researchers. For more details, please visit Oligonucleotide Synthesis Services Market landscape, Top Competitor Analysis, Revenue, Sales With Forecast Data from 2022 to 2028.

 

Selected Published Papers

SBS Genetech supplies high-quality oligonucleotides, empowering researchers to publish over 800 papers in prestigious journals such as Nucleic Acids Research, Biosensors and Bioelectronics, and Blood

_{Measuring specific interaction of transcription factor ZmDREB1A with its DNA responsive element at the molecular level}

_{Nucleic Acids Research | 01 Jan 2004 | DOI: https://doi.org/10.1093/nar/gnh100}

_{All the DNA sequences were custom synthesized from SBS Genetech Co. Ltd. (Beijing, China). These include the DRE element sequence (ACCGAC), 5′-NH 2 -GATATACT ACCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTGTACTCAAG-5′; the DRE element sequence (GCCGAC), 5′-NH 2 -GATATACT GCCGAC ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGACGGCTGTACTCAAG-5′; the ERE element (GCCGCC), 5′-NH 2 -CGCAGACATA GCCGCC ATTT-3′, and its complementary ssDNA, 3′-GCGTCTGTATCGGCGGTAAA-5′; the mutant DRE element sequence (ACCGAG), 5′-NH 2 -GATATACT ACCGAG ATGAGTTC-3′, and its complementary ssDNA, 3′-CTATATGATGGCTCTACTCAAG-5′ (the element sequences are underlined).}

 

_{Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant}

_{Blood | 01 March 2004 | DOI: https://doi.org/10.1182/blood-2003-08-2828}

_{To assess Hsp70L1 expression in DCs, 6-day DCs generated from human peripheral monocytes were stimulated at 5 × 105 cells/mL for 8 hours with 1 μg/mL lipopolysaccharide (LPS) (Sigma), 30 μg/mL CpG oligonucleotides (5′-TCGTCGTTCCCCCCCCCC-CC-3′; SBS Genetech, Beijing, China)}

 

_{A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes}

_{Nucleic Acids Research | 30 Aug 2008 | DOI: https://doi.org/10.1093/nar/gkn543}

_{HPLC purified oligonucleotides were procured from SBS Genetech, China. The concentrations of these oligonucleotides were calculated by extrapolation of tabulated values of the monomer bases and dimers at 25°C using procedures reported earlier}

 

_{Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation}

_{Biosensors and Bioelectronics | 31 Oct 2014 | DOI: https://doi.org/10.1016/j.bios.2014.10.055}

_{Deoxyribonucleoside 5′-triphosphates (dNTPs) mixture and all oligonucleotides as depicted in Table S1 of Supporting information were purchased from SBS Genetech. Co. Ltd. (China).}

 

_{Electrochemical aptasensor based on one-step synthesis of Cu2O@aptamer nanospheres for sensitive thrombin detection}

_{Sensors and Actuators B: Chemical | 10 June 2015 | DOI: https://doi.org/10.1016/j.snb.2015.05.089}

_{Blood sera and aptamer were acquired from SBS Genetech Co. Ltd. (Beijing, China) and has the following sequences: 5′-TCTCTCAGTCCGTGGTAGGGCAGGGTTGGGGTGACT-3′......}

 

_{Carbon-based nanocomposites with aptamer-templated silver nanoclusters for the highly sensitive and selective detection of platelet-derived growth factor}

_{Biosensors and Bioelectronics | 16 Nov 2016 | DOI: https://doi.org/10.1016/j.bios.2016.11.019}

_{Aptamer was obtained from SBS Genetech Co., Ltd. (Beijing, China), and the sequence was: 5′-CAG GCT ACG GCA CGT AGA GCA TCA CCA TGA TCC}

 

_{Fe(III)-based metal–organic framework-derived core–shell nanostructure: Sensitive electrochemical platform for high trace determination of heavy metal ions}

_{Biosensors and Bioelectronics | 17 Mar 2017 | DOI: https://doi.org/10.1016/j.bios.2017.03.014}

_{Aptamer strands were obtained from SBS Genetech Co. Ltd (Beijing, China).}

 

_{A CRISPR/Cas12a-based fluorescence aptasensor for the rapid and sensitive detection of ampicillin}

_{International Journal of Biological Macromolecules | 9 June 2023 | DOI: https://doi.org/10.1016/j.ijbiomac.2023.125211}

_{The oligonucleotides employed in this experiment were procured from Beijing SBS Genetech Co. Ltd. (China). The sequences of the reporter and three aptamers were obtained in accordance with their relevant references [36,37], while crRNA and activator DNA sequences were designed in our laboratory.}

 

_{Smart co-delivery of plasmid DNA and doxorubicin using MCM-chitosan-PEG polymerization functionalized with MUC-1 aptamer against breast cancer}

_{Biomedicine & Pharmacotherapy | 19 March 2024 | DOI: https://doi.org/10.1016/j.biopha.2024.116465}

_{The aptamer used (sequence: 5′-GCCCGCCGTGGCTGGGTCTTCCTTGGTCGGTCTACAAAAAAAAAA-SH-3′) was obtained from SBS Genetech Co. Ltd.}

 

_{Exploring aptamer-aTF sandwich and CRISPR-Cas12a methods for sensitive L-lactate biosensing in human serum and saliva}

_{Sensors and Actuators B: Chemical | 28 November 2024 | DOI: https://doi.org/10.1016/j.snb.2024.137015}

_{The oligonucleotides utilised in this study were obtained from Beijing SBS Genetech Co. Ltd. (Beijing, China). The sequences of the dsDNA, reporter, and aptamers were obtained following their relevant references while gRNA...}

 

_{Nucleic acid-free aptamer-CRISPR/Cas14 biosensor for prosthetic joint infection rapid detection}

_{Sensors and Actuators Reports | 24 March 2025 | DOI: https://doi.org/10.1016/j.snr.2025.100318}

_{Nucleotide sequences were synthesized by Beijing SBS Genetech Co., Ltd.}