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- About
  About SBS
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from China, for the World
for Superior Biology Services since 2000

Home
Products
All Products
Custom Services
Catalog Products
Innovative Systems
Nucleic Acid Related
Enzymes
POCT
Integrated POCT Platform
LAMP
RPA
CRISPR
DNA-Free Enzymes
Lateral Flow System
Freeze-Drying System
About
About SBS
Solutions
Achievements
Legal Statement
Contact
- Home
- Products
  All Products
  Custom Services
  Catalog Products
  Innovative Systems
  Nucleic Acid Related
  Enzymes
- POCT
  Integrated POCT Platform
  LAMP
  RPA
  CRISPR
  DNA-Free Enzymes
  Lateral Flow System
  Freeze-Drying System
- About
  About SBS
  Solutions
  Achievements
  Legal Statement
- Contact

- Login

pCMV-Cre-mCherry 6 1 1

pCMV-Cre-mCherry is an expression plasmid containing the CMV promoter for expressing Cre Recombinase tagged with mCherry (a bright red fluorescent protein, a mutant of DsRed) in mammalian cells. When cells harboring pre-inserted loxP sites, such as those derived from conditional knockout mice, are transfected with this plasmid, Cre Recombinase expressed by the plasmid mediates deletion of the sequence flanked by two loxP sites, enabling conditional gene knockout.

pCMV-dCas9-TET1

pCMV-dCas9-TET1 is a plasmid that uses the CRISPR/dCas9 gene regulation system to carry out targeted DNA demethylation modification. This plasmid fuses and expresses dCas9 protein with methylcytosine dioxygenase 1 (TET1). After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, DNA methylation regulation of single or multiple target genes can be achieved.

pCMV-dCas9-DNMT3A

pCMV-dCas9-DNMT3A is a plasmid that uses the CRISPR/dCas9 gene regulation system to carry out targeted DNA methylation modification. This plasmid fuses and expresses dCas9 protein and DNA methyltransferase 3α. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, DNA methylation regulation of single or multiple target genes can be achieved.

pCMV-dCas9-DNMT3B

pCMV-dCas9-DNMT3B is a plasmid that uses the CRISPR/dCas9 gene regulation system to carry out targeted DNA methylation modification. This plasmid fuses and expresses dCas9 protein and DNA methyltransferase 3β. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, DNA methylation regulation of single or multiple target genes can be achieved.

pCMV-dCas9-DNMT1

pCMV-dCas9-DNMT1 is a plasmid that uses the CRISPR/dCas9 gene regulation system to carry out targeted DNA methylation modification. This plasmid fuses and expresses dCas9 protein with DNA methyltransferase 1 (DNMT1). After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, DNA methylation regulation of single or multiple target genes can be achieved.

pCMV-dCas9-KRAB

pCMV-dCas9-KRAB is a plasmid that utilizes the CRISPR/dCas9 gene regulation system for gene transcription inhibition (CRISPRi). The plasmid fuses the expression of dCas9 protein with the transcriptional repressor KRAB. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional inhibition or downregulation of single or multiple target genes can be achieved.

pCMV-dCas9-VP160

pCMV-dCas9-VP160 is a plasmid that utilizes the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). This plasmid fuses and expresses the dCas9 protein and the transcriptional activator VP160. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional activation or upregulation of single or multiple target genes can be achieved.

pCMV-MS2-P65-NLS-HSF1

pCMV-MS2-p65-NLS-HSF1 is a plasmid that utilizes the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). This plasmid fuses to express the RNA-binding protein MS2 and the transcriptional activator p65. After co-transfection into mammalian cells with the pCMV-dCas9-VP64 plasmid and the sgRNA (Single guide RNA) encoding plasmid targeting the target gene and containing the MS2-specific domain, the MS2 domain can specifically recognize and bind the sgRNA containing the MS2 stem loop, and use p65 and HSF1 to coordinately recruit transcription complexes, thereby achieving efficient transcriptional activation of specific genes.

pCMV-dCas9-VPR

pCMV-dCas9-VPR is a plasmid that uses the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). The plasmid fuses and expresses the dCas9 protein with the transcriptional activators VP64, p65, and Rta. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional activation or upregulation of single or multiple target genes can be achieved.

pCMV-dCas9-Rta

pCMV-dCas9-Rta is a plasmid that uses the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). This plasmid fuses and expresses the dCas9 protein and the transcriptional activator Rta. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional activation or upregulation of single or multiple target genes can be achieved.

pCMV-dCas9-P65

pCMV-dCas9-p65 is a plasmid that uses the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). This plasmid fuses and expresses the dCas9 protein and the transcriptional activator p65. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional activation or upregulation of single or multiple target genes can be achieved.

pCMV-dCas9-VP64

pCMV-dCas9-VP64 is a plasmid that uses the CRISPR/dCas9 gene regulation system for gene transcription activation (CRISPRa). This plasmid fuses and expresses the dCas9 protein and the transcriptional activator VP64. After co-transfection into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the transcriptional activation or upregulation of single or multiple target genes can be achieved.

pLenti-dCas13-FTO-IRES-Puro

pLenti-dCas13-FTO-IRES-Puro is a plasmid that uses the CRISPR/dCas13 gene regulation system for targeted RNA demethylation modification and lentiviral packaging. The plasmid fuses to express the dCas13 protein and m6A demethylase FTO. On the one hand, after the plasmid is co-transfected into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target single-stranded RNA (ssRNA), RNA methylation regulation of single or multiple target ssRNAs can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro is a plasmid that uses the CRISPR/dCas13 gene regulation system for targeted RNA methylation modification and lentiviral packaging. The plasmid fuses and expresses dCas13 protein with methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target single-stranded RNA (ssRNA) in mammalian cells, RNA methylation regulation of single or multiple target ssRNAs can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro is a plasmid that uses the CRISPR/dCas13 gene regulation system for targeted RNA methylation modification and lentiviral packaging. The plasmid fuses and expresses dCas13 protein with methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target single-stranded RNA (ssRNA) in mammalian cells, RNA methylation regulation of single or multiple target ssRNAs can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas13-M3-IRES-Puro

pLenti-dCas13-M3-IRES-Puro is a plasmid that uses the CRISPR/dCas13 gene regulation system for targeted RNA methylation modification and lentiviral packaging. The plasmid fuses and expresses dCas13 protein and methyltransferase-like protein 3 (METTL3). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target single-stranded RNA (ssRNA) in mammalian cells, RNA methylation regulation of single or multiple target ssRNAs can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas9-HDAC3-IRES-Puro

pLenti-dCas9-HDAC3-IRES-Puro is a plasmid that uses the CRISPR/dCas9 gene regulation system for histone deacetylation and lentiviral packaging. The plasmid fuses and expresses dCas9 protein and histone deacetylase 3 (HDAC3). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene into mammalian cells, the histone acetylation control of single or multiple target genes can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas9-HDAC1-IRES-Puro

pLenti-dCas9-HDAC1-IRES-Puro is a plasmid that uses the CRISPR/dCas9 gene regulation system for histone deacetylation and lentiviral packaging. The plasmid fuses and expresses dCas9 protein and histone deacetylase 1 (HDAC1). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene into mammalian cells, the histone acetylation control of single or multiple target genes can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas9-Sir2a-IRES-Puro

pLenti-dCas9-Sir2a-IRES-Puro is a plasmid that uses the CRISPR/dCas9 gene regulation system for histone deacetylation and lentiviral packaging. The plasmid fuses and expresses dCas9 protein and silent information regulator 2 (Sir2a). On the one hand, after co-transfection of the plasmid with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene into mammalian cells, the histone acetylation control of single or multiple target genes can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

pLenti-dCas9-GCN5-IRES-Puro

pLenti-dCas9-GCN5-IRES-Puro is a plasmid that uses the CRISPR/dCas9 gene regulation system for histone acetylation modification and lentiviral packaging. The plasmid fuses to express the dCas9 protein and the histone acetyltransferase GCN5. On the one hand, after the plasmid is co-transfected into mammalian cells with the sgRNA (Single guide RNA) encoding plasmid targeting the target gene, the histone acetylation control of single or multiple target genes can be achieved. On the other hand, this plasmid can also be used to co-transfect HEK-293T cells with pCMV-VSV-G plasmid and pCAG-dR8.9 (delta8.9, Δ8.9) to package lentivirus.

All Categories - SBS Genetech - for Superior Biology Services since 2000

pCMV-Cre-mCherry 6 1 1

pCMV-dCas9-TET1

pCMV-dCas9-DNMT3A

pCMV-dCas9-DNMT3B

pCMV-dCas9-DNMT1

pCMV-dCas9-KRAB

pCMV-dCas9-VP160

pCMV-MS2-P65-NLS-HSF1

pCMV-dCas9-VPR

pCMV-dCas9-Rta

pCMV-dCas9-P65

pCMV-dCas9-VP64

pLenti-dCas13-FTO-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-IRES-Puro

pLenti-dCas9-HDAC3-IRES-Puro

pLenti-dCas9-HDAC1-IRES-Puro

pLenti-dCas9-Sir2a-IRES-Puro

pLenti-dCas9-GCN5-IRES-Puro

Precision Molecular Technologies

from Research to Commercial Scale

For over 25 years, SBS Genetech has delivered
high-quality, rigorously validated molecular reagents
trusted by leading research institutions and
biotechnology companies across 60+ countries.

Scientific Validation Behind Our Technologies

We are honored to create value for our customers and facilitate the development of science

All Categories - SBS Genetech - for Superior Biology Services since 2000

pCMV-Cre-mCherry 6 1 1

pCMV-dCas9-TET1

pCMV-dCas9-DNMT3A

pCMV-dCas9-DNMT3B

pCMV-dCas9-DNMT1

pCMV-dCas9-KRAB

pCMV-dCas9-VP160

pCMV-MS2-P65-NLS-HSF1

pCMV-dCas9-VPR

pCMV-dCas9-Rta

pCMV-dCas9-P65

pCMV-dCas9-VP64

pLenti-dCas13-FTO-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-M14-IRES-Puro

pLenti-dCas13-M3-IRES-Puro

pLenti-dCas9-HDAC3-IRES-Puro

pLenti-dCas9-HDAC1-IRES-Puro

pLenti-dCas9-Sir2a-IRES-Puro

pLenti-dCas9-GCN5-IRES-Puro

Precision Molecular Technologies

from Research to Commercial Scale

For over 25 years, SBS Genetech has delivered high-quality, rigorously validated molecular reagents trusted by leading research institutions and biotechnology companies across 60+ countries.

Scientific Validation Behind Our Technologies

We are honored to create value for our customers and facilitate the development of science

For over 25 years, SBS Genetech has delivered
high-quality, rigorously validated molecular reagents
trusted by leading research institutions and
biotechnology companies across 60+ countries.