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Cat. No.: VBCS-0.2 (for 10mM×0.2ml)

Cat. No.: VBCS-5 (for 5mg)

Cat. No.: VBCS-25 (for 25mg)

Cat. No.: VBCS-100 (for 100mg)

Description

Verbascoside, extracted from Lantana camara, functions as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM. It possesses notable antitumor, anti-inflammatory, and antineuropathic pain properties.

Basic Information

• Aliases: Acteoside; Kusaginin; TJC160
• Source: Callicarpa macrophylla Vahl; Cistanche deserticola Ma; Lantana camara L.
• Compound type: Phenylpropanoids > Phenylpropanoic acids
• Chemical Formula: C₂₉H₃₆O₁₅
• Molecular Weight: 624.59
• CAS Number: 61276-17-3
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO : ≥ 100 mg/ml (160.11 mM)
• Solution Preparation: Add 10mg to 1.60ml of DMSO, or add 6.25mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

-

In Vitro Study

Verbascoside functions as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM. Additionally, it exhibits Kis of 22 and 28 µM concerning ATP and histone, respectively. Verbascoside demonstrates potent antitumor activity against L-1210 cells, with an IC50 of 13 µM. Moreover, at concentrations of 5 and 10 µM, Verbascoside suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells.

In Vivo Study

Verbascoside (1%) not only decreases the overall incidence of scratching behavior but also alleviates the severity of skin lesions in the 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. It effectively blocks the DNCB-induced expression of proinflammatory cytokines TNF-α, IL-6, and IL-4 mRNA in skin lesions.

In terms of chronic constriction injury (CCI)-induced cold allodynia, Verbascoside (50, 100 mg/kg, i.p.) does not induce modifications. However, at a dose of 200 mg/kg, i.p., it reduces hypersensitivity to cold stimulus (acetone) on day 3 in rats, accompanied by a significant decrease in behavioral changes associated with neuropathy. Furthermore, Verbascoside leads to a decrease in Bax expression and an increase in Bcl-2 expression on day 3.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory