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Cat. No.: UGN2-50-95 (for 50mg, 95% purity)

Cat. No.: UGN2-50-98 (for 50mg, 98% purity)

Cat. No.: UGN2-1k-95 (for 1g, 95% purity)

Cat. No.: UGN2-1k-98 (for 1g, 98% purity)

Description

UDP-GlcNAc.2Na, or uridine diphosphate N-acetylglucosamine disodium salt, is a nucleotide sugar that plays a critical role in glycosylation and carbohydrate metabolism. It is an activated form of N-acetylglucosamine (GlcNAc) and serves as a donor substrate for glycosyltransferase enzymes. These enzymes transfer GlcNAc residues to various acceptor molecules, enabling the biosynthesis of glycans, glycoproteins, and glycolipids.

Features

• Molecular Composition: UDP-GlcNAc consists of a uridine diphosphate (UDP) group linked to N-acetylglucosamine. The disodium salt form enhances its solubility and stability.
• Molecular Formula: C₁₇H₂₅N₃O₁₇P₂·2Na.
• Molecular Weight: Approximately 651.32 g/mol.

Applications

Glycosylation Studies:

• UDP-GlcNAc is a key substrate for glycosyltransferases involved in the synthesis of N-linked and O-linked glycans, which are essential for protein folding, stability, and function.
• It is also used in the study of O-GlcNAcylation, a post-translational modification that regulates cellular processes such as signaling, transcription, and metabolism.

Carbohydrate Metabolism:

• UDP-GlcNAc is a product of the hexosamine biosynthetic pathway, which integrates glucose, amino acids, fatty acids, and nucleotide metabolism.
• It is involved in the biosynthesis of glycosaminoglycans (e.g., hyaluronic acid, heparan sulfate) and glycolipids.

Cellular and Molecular Research:

• Researchers use UDP-GlcNAc to investigate the roles of glycans in cell-cell communication, immune response, and disease progression.
• It is also studied for its role in insulin signaling and glucose sensing.

CAS Number: 91183-98-1

Molecular Formula: C17H25N3O17P2Na2

Molecular Weight: 651.32

Purity: 95%, 98%

Only for research and not intended for treatment of humans or animals

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