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Cat. No.: SCSD-0.2 (for 10mM×0.2ml)

Cat. No.: SCSD-5 (for 5mg)

Cat. No.: SCSD-25 (for 25mg)

Cat. No.: SCSD-100 (for 100mg)

Description

Schisandrin (also known as Schizandrin), a dibenzocyclooctadiene lignan, is extracted from the fruit of Schisandra chinensis Baill. It demonstrates antioxidant, hepatoprotective, anti-cancer, and anti-inflammatory properties. Additionally, Schisandrin has been shown to reverse memory impairment in rats.

Basic Information

• Aliases: Wuweizichun A; Wuweizi alcohol A; Schisandrin; Schisandrol A
• Source: Schisandra chinensis (Turcz.) Baill.
• Compound type: Phenylpropanoids > Lignans > Dibenzocyclooctadiene
• Chemical Formula: C₂₄H₃₂O₇
• Molecular Weight: 432.51
• CAS Number: 7432-28-2
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 4.33 mg/ml (10 mM)
• Solution Preparation: 5mg added to 1.16ml DMSO, or 4.33mg added to 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

Inflammation; Apoptosis

In Vitro Study

Schisandrin (10-100 μM; pretreated for 2 h) dose-dependently inhibits LPS-stimulated NO production, iNOS protein, and mRNA expression in RAW 264.7 cells. Additionally, Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein, and mRNA expression in LPS-stimulated RAW 264.7 macrophages. Moreover, Schisandrin inhibits the proliferation of SK-HEP-1, SNU-638, and T47D cells, with IC50s of 42.0, 53.1, and 40.0 μM, respectively. Schisandrin (10-60 μM; 48 h) enhances Doxorubicin-induced apoptosis and selectively reverses MCF-7/DOX resistance.

In Vivo Study

Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces carrageenan-induced paw edema in mice. Additionally, Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses Scopolamine-induced impairment of spatial memory and passive avoidance response and enhances tremors induced by Oxotremorine in rats.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory