All products have special prices for bulk purchase, please contact for more details if required.

Cat. No.: SAB-5 (for 5mg)

Cat. No.: SAB-25 (for 25mg)

Cat. No.: SAB-100 (for 100mg)

Description

Salvianolic acid B, an active compound found in Salvia miltiorrhiza, has been extensively utilized in China for treating various microcirculation-related disorders, including cardiovascular disease, cerebrovascular disease, and diabetic vascular complications.

Basic Information

• Aliases: Lithospermic acid B; Danshensuan B
• Source: Salvia miltiorrhiza Bunge
• Compound type: Phenylpropanoids > Phenylpropanoic acids
• Chemical Formula: C₃₆H₃₀O₁₆
• Molecular Weight: 718.61
• CAS Number: 121521-90-2
• Purity: 98%, HPLC
• Solvent/Solubility: Water: 50 mg/ml (69.58 mM; adjust pH to 3 with HCl); DMSO: 25 mg/ml (34.79 mM)
• Solution Preparation: Add 10mg to 1.39ml of DMSO, or add 7.19mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

Inflammatory

In Vitro Study

Salvianolic acid B (SA-B) at concentrations of 1 and 10 micromoles per liter reduces active TGF-beta1 secretion by 63.3% and 15.6% respectively compared to control, while downregulating pro-collagen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B at concentrations of 1 and 10 micromoles per liter also inhibits MAPK activity by 1 to 2-fold respectively. The degradation of Salvianolic acid B is temperature-dependent. It remains stable at 4ºC for 30 hours in an aqueous solution. However, decomposition of Salvianolic acid B in aqueous solution occurs spontaneously at 25ºC, and is accelerated at 37ºC, 65ºC, and 100ºC. Conversely, Salvianolic acid B remains stable for 30 hours at 4ºC, 25ºC, and 37ºC in TPA (total phenolic acids). Furthermore, Salvianolic acid B maintains stability for 30 hours in buffered phosphate aqueous solutions at pH 1.5, 3.0, and 5.0. However, with an increase in pH from neutral, the stability of Sal B decreases.

In Vivo Study

Salvianolic acid B (SalB) at a dose of 5 mg/kg/h significantly mitigates LPS-induced pulmonary microcirculatory disturbances, including the elevation in leukocyte adhesion and albumin leakage. Furthermore, LPS administration leads to an increase in pulmonary tissue wet-to-dry weight ratio, as well as elevated levels of tumor necrosis factor [alpha] and interleukin 8 in plasma and bronchoalveolar lavage fluid, accompanied by heightened expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, while decreasing the expression of AQP-1 and AQP-5 in pulmonary tissue; all of which are mitigated by SalB pretreatment. Additionally, SalB administration at a dose of 10 mg/kg significantly improves Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduces the activation of microglia and astrocytes observed during the inflammatory reaction following Aβ25-35 peptide administration. Moreover, SalB markedly reduces the expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as thiobarbituric acid reactive substances, which are elevated by Aβ25-35 peptide administration. Furthermore, SalB administration significantly rescues the Aβ25-35 peptide-induced decrease in choline acetyltransferase and brain-derived neurotrophic factor protein levels.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

Journals Using SBS Genetech Products                                       Universities Using SBS Genetech Products

SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory