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Cat. No.: SFLM-0.2 (for 10mM×0.2ml)

Cat. No.: SFLM-5 (for 5mg)

Cat. No.: SFLM-25 (for 25mg)

Cat. No.: SFLM-100 (for 100mg)

Description

Hydroxysafflor yellow A, a flavonoid compound derived from the traditional Chinese medicine Carthamus tinctorius L., exhibits anti-tumor activity.

Basic Information

• Aliases: Hydroxy safflor yellow A; HSYA
• Source: Carthamus tinctorius L.
• Compound type: Flavonoids > Chalcones
• Chemical Formula: C₂₇H₃₂O₁₆
• Molecular Weight: 612.53
• CAS Number: 78281-02-4
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 34 mg/ml (55.51 mM); Water: 33.33 mg/ml (54.41 mM)
• Solution Preparation: 10 mg added to 1.63 ml of DMSO, or 6.13 mg added to 1 ml of DMSO, to prepare a 10 mM solution.

Signaling Pathway

In Vitro Study

HYSA inhibits LPS-induced VSMC proliferation and migration, along with decreased levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-8. Additionally, HYSA inhibits LPS-induced upregulation of TLR-4 expression and activation of the Rac1/Akt pathway. HSYA protects EC viability against LPS-induced injury (P<0.05) by inhibiting LPS-induced NF-κB p65 subunit DNA binding (P<0.01) and phosphorylation of NF-κB inhibitor-α (I-κB-α). Moreover, HSYA attenuates LPS-triggered elevation of ICAM-1 and E-selectin mRNA levels, as well as phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. HSYA inhibits the proliferation of 3T3-L1 preadipocytes, with cell viability decreasing in a dose- and time-dependent manner. Notably, HSYA (1 mg/l) significantly reduces intracellular lipid and triglyceride content in adipocytes by 21.3% (2.13 ± 0.36 vs 2.71 ± 0.40, P < 0.01) and 22.6% (1.33 ± 0.07 vs 1.72 ± 0.07, P < 0.01) on days 8 following differentiation, respectively.

In Vivo Study

HSYA treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronan (HA), laminin (LN), and type III precollagen (III-C) in rats.

Clinical Trial

N/A

Storage

Store at -20°C in the dark, stable for at least one year. Store solid powder at 4°C in the dark, stable for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C in the dark, stable for an estimated six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory