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Cat. No.: CMPK1-10 (for 10μg)

Cat. No.: CMPK1-50 (for 50μg)

Cat. No.: CMPK1-200 (for 200μg)

Cat. No.: CMPK1-1k (for 1mg)

Description

Recombinant Human CMPK1 (His-Tag) was expressed in E. coli and purified, which contains the full length of human CMPK1 (Pro2-Gly196) with His-Tag fusion at the N-terminus. CMPK1, also known as UMP-CMP kinase is part of the nucleotide metabolism network, which is responsible for the synthesis and interconversion of nucleotides that are essential for cellular activities. This enzymatic activity is of importance in the de novo biosynthesis of pyrimidine nucleotides, representing a critical step in the synthesis of essential cellular components. During this process, CMPK1 preferentially selects uridine monophosphate (UMP) and cytidine monophosphate (CMP) as phosphate receptors. Additionally, CMPK1 exhibits extensive nucleoside diphosphate kinase activity, demonstrating its versatility in catalyzing the transfer of phosphate groups between different nucleoside diphosphates. The multifaceted functions of CMPK1 reveal its pivotal role in cellular nucleotide metabolism and its potential impact on various cellular processes.

Applications

Study of nucleotide metabolism, enzymatic activity and cellular processes that rely on nucleotide biosynthesis.

Concentration

~1mg/ml

Purity

≥95% by SDS-PAGE

Storage Conditions​

Store at -20 °C; stable for at least one year. Longer-term storage is achievable at -80 °C.

Precautions

• Each freeze-thaw cycle may cause partial inactivation of the protein. After preparing the stock solution at the required concentration for the first time, aliquot and store at -20 °C or lower to avoid repeated freeze-thaw cycles as much as possible.
• This product is intended solely for scientific research use by professionals. It shall not be used for clinical diagnosis or treatment, food or pharmaceutical applications, and must not be stored in residential premises.
• For your safety and health, wear a lab coat and disposable gloves during handling.

Only for research and not intended for treatment of humans or animals

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